2,5-DICHLORO-6-FLUOROBENZIMIDAZOLE

Base Information

• Chemical Name: 2,5-DICHLORO-6-FLUOROBENZIMIDAZOLE
• CAS No.: 142356-65-8
• Molecular Formula: C₇H₃Cl₂FN₂
• Molecular Weight: 205.019
• Hs Code.: 2933998090
• Mol file: 142356-65-8.mol

Synonyms:1H-Benzimidazole,2,5-dichloro-6-fluoro- (9CI); 2,5-Dichloro-6-fluoro-1H-benzimidazole

Chemical Property of 2,5-DICHLORO-6-FLUOROBENZIMIDAZOLE

Chemical Property:

• PSA: 28.68000
• LogP: 3.00880

Purity/Quality:

97% ^*data from raw suppliers

2,5-Dichloro-6-fluoro-1H-benzimidazole 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-DICHLORO-6-FLUOROBENZIMIDAZOLE

There total 2 articles about 2,5-DICHLORO-6-FLUOROBENZIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

5-chloro-6-fluoro-1H-benzo[d]imidazol-2(3H)-one (1075753-25-1) → 2,5-dichloro-6-fluoro-1H-benzo[d]imidazole (142356-65-8)

Guidance literature:

With trichlorophosphate; at 120 ℃; for 2h;

Reference yield:

4-chloro-5-fluorobenzene-1,2-diamine (139512-70-2) → 2,5-dichloro-6-fluoro-1H-benzo[d]imidazole (142356-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2: trichlorophosphate / 2 h / 120 °C

With trichlorophosphate; In tetrahydrofuran;

Reference yield:

2-(3-chloro-4-fluorophenyl)-3-(pyridin-2-yl)-2,7-diazaspiro[3.5]nonan-1-one (1012332-12-5,1012332-13-6,1012332-15-8) + C7H3Cl2FN2 (142356-65-8) → C25H19Cl2F2N5O (1012332-00-1,1012332-05-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; at 175 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;

DOI:10.1016/j.bmcl.2010.06.012

upstream raw materials:

5-chloro-6-fluoro-1H-benzo[d]imidazol-2(3H)-one

4-chloro-5-fluorobenzene-1,2-diamine

Downstream raw materials:

C₂₅H₁₉Cl₂F₂N₅O

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