5-(2-METHOXYPHENYL)-1H-TETRAZOLE

Base Information

• Chemical Name: 5-(2-METHOXYPHENYL)-1H-TETRAZOLE
• CAS No.: 51449-81-1
• Molecular Formula: C8H8N4O
• Molecular Weight: 176.178
• Hs Code.: 2933990090
• Mol file: 51449-81-1.mol

Synonyms:5-(2-METHOXYPHENYL)-1H-TETRAZOLE;5-(2-METHOXYPHENYL)-2H-TETRAZOLE

Chemical Property of 5-(2-METHOXYPHENYL)-1H-TETRAZOLE

Chemical Property:

• Vapor Pressure: 6.41E-06mmHg at 25°C
• Melting Point: 154-156°C
• Refractive Index: 1.591
• Boiling Point: 378.2°Cat760mmHg
• Flash Point: 137.6°C
• PSA: 63.69000
• Density: 1.288g/cm³
• LogP: 0.87530

Purity/Quality:

99% ^*data from raw suppliers

5-(2-Methoxyphenyl)-1H-tetrazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(2-METHOXYPHENYL)-1H-TETRAZOLE

There total 11 articles about 5-(2-METHOXYPHENYL)-1H-TETRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ortho-anisaldehyde (135-02-4) → 5-(2-methoxyphenyl)-1H-tetrazole (51449-81-1)

Guidance literature:

With sodium azide; hydroxylamine hydrochloride; In water; at 20 ℃; for 0.0833333h; Green chemistry;

DOI:10.1039/c6ra19631d

Reference yield: 95.0%

2-methoxy-benzonitrile (6609-56-9) → 5-(2-methoxyphenyl)-1H-tetrazole (51449-81-1)

Guidance literature:

With tributyltin azide; In xylene; Heating;

DOI:10.1021/jo991236s

Reference yield: 88.0%

potassium cyanide + 2-Methoxyphenylboronic acid (5720-06-9) → 5-(2-methoxyphenyl)-1H-tetrazole (51449-81-1)

Guidance literature:

With sodium azide; potassium carbonate; In ethanol; water; for 1.7h; Catalytic behavior; Reflux; Inert atmosphere; Green chemistry;

DOI:10.1016/j.mcat.2021.111489

upstream raw materials:

2-methoxy-benzonitrile

N⁽²⁾-cumyl-5-(2-methoxyphenyl)tetrazole

2-methoxybenzamide

2-Methoxybenzoyl chloride

Downstream raw materials:

N⁽²⁾-cumyl-5-(2-methoxyphenyl)tetrazole

2-(2-methoxyphenyl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole

N⁽²⁾-cumyl-5-(4'-(dimethoxymethyl)[1,1'-biphenyl]-2-yl)tetrazole

Refernces

• 1、 Bagherzade, Ghodsieh,Ghamari kargar, Pouya. "The anchoring of a Cu(ii)-salophen complex on magnetic mesoporous cellulose nanofibers: green synthesis and an investigation of its catalytic role in tetrazole reactions through a facile one-pot route". . p. 19203 - 19220. Retrieved 2021/06/03.
• 2、 Zhang, Yuan,Lee, Jack Chang Hung,Reese, Matthew R.,Boscoe, Brian P.,Humphrey, John M.,Helal, Christopher J.. "5-Aryltetrazoles from Direct C-H Arylation with Aryl Bromides". . p. 5718 - 5723. Retrieved 2020/05/19.