Cyclobutanecarboxylic acid, 3-(aminocarbonyl)-, methyl ester, cis- (9CI)

Base Information

• Chemical Name: Cyclobutanecarboxylic acid, 3-(aminocarbonyl)-, methyl ester, cis- (9CI)
• CAS No.: 142733-62-8
• Molecular Formula: C₇H₁₁NO₃
• Molecular Weight: 157.169
• Mol file: 142733-62-8.mol

Synonyms:cis-Methyl3-(aminocarbonyl)cyclobutanecarboxylate

Chemical Property of Cyclobutanecarboxylic acid, 3-(aminocarbonyl)-, methyl ester, cis- (9CI)

Chemical Property:

• PSA: 69.39000
• LogP: 0.37120

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclobutanecarboxylic acid, 3-(aminocarbonyl)-, methyl ester, cis- (9CI)

There total 6 articles about Cyclobutanecarboxylic acid, 3-(aminocarbonyl)-, methyl ester, cis- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

cis-1,3-cyclobutanedicarboxylic acid monomethyl ester (142733-61-7,116569-00-7,1401103-71-6) → cis-methyl 3-carboxamidocyclobutanecarboxylate (142733-62-8)

Guidance literature:

cis-1,3-cyclobutanedicarboxylic acid monomethyl ester; With 1,1'-carbonyldiimidazole; In ethyl acetate; at 20 ℃; for 1h;

With ammonium hydroxide; In ethyl acetate; at 20 ℃; for 0.5h;

Reference yield:

3-Ethoxycarbonyloxycarbonyl-cyclobutanecarboxylic acid methyl ester → cis-methyl 3-carboxamidocyclobutanecarboxylate (142733-62-8)

Guidance literature:

With ammonia; In dichloromethane; at 0 ℃; for 3h; Yield given;

Reference yield:

cis-cyclobutane-1,3-dicarboxylic acid anhydride (4462-97-9) → cis-methyl 3-carboxamidocyclobutanecarboxylate (142733-62-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / Et₃N / tetrahydrofuran / 10 h / Ambient temperature

2: CH₂Cl₂ / 0.5 h / 0 °C

3: NH₃ / CH₂Cl₂ / 3 h / 0 °C

With ammonia; triethylamine; In tetrahydrofuran; dichloromethane;

upstream raw materials:

cis-cyclobutane-1,3-dicarboxylic acid anhydride

7‐phenyl‐6,8‐dioxaspiro[3.5]nonane‐2,2‐dicarboxylic acid

cis-1,3-cyclobutanedicarboxylic acid monomethyl ester

1,1,3,3-cyclobutanetetracarboxylic acid

Downstream raw materials:

cis-methyl 3-<(t-butoxycarbonyl)amino>cyclobutanecarboxylate