2H-Pyran-2-aceticacid,6-ethoxy-3,6-dihydro-3-hydroxy-,[2R-(2alpha,3bta,6bta)]-(9CI)

Base Information

Chemical Name:2H-Pyran-2-aceticacid,6-ethoxy-3,6-dihydro-3-hydroxy-,[2R-(2alpha,3bta,6bta)]-(9CI)
CAS No.:148379-83-3
Molecular Formula:C₉H₁₄O₅
Molecular Weight:202.207
Hs Code.:
Mol file:148379-83-3.mol

Synonyms:2H-Pyran-2-aceticacid,6-ethoxy-3,6-dihydro-3-hydroxy-,[2R-(2alpha,3bta,6bta)]-(9CI)

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Chemical Property of 2H-Pyran-2-aceticacid,6-ethoxy-3,6-dihydro-3-hydroxy-,[2R-(2alpha,3bta,6bta)]-(9CI)

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Technology Process of 2H-Pyran-2-aceticacid,6-ethoxy-3,6-dihydro-3-hydroxy-,[2R-(2alpha,3bta,6bta)]-(9CI)

There total 8 articles about 2H-Pyran-2-aceticacid,6-ethoxy-3,6-dihydro-3-hydroxy-,[2R-(2alpha,3bta,6bta)]-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 148379-80-0
Ethyl 2,3,6-trideoxy-α-D-erythro-hept-2-enopyranurononitrile

: 148379-83-3
Ethyl 2,3,6-trideoxy-α-D-erythro-hept-2-enopyranuronic acid

Guidance literature:: for 168h; Ambient temperature; immobilized SP₄₀₉ nitrilase, aq. phosphate buffer;
DOI:10.1021/jo00063a048

Reference yield:

: 55735-68-7
Acetic acid (2R,3S,6S)-6-ethoxy-2-hydroxymethyl-3,6-dihydro-2H-pyran-3-yl ester

: 148379-83-3
Ethyl 2,3,6-trideoxy-α-D-erythro-hept-2-enopyranuronic acid

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / CH₂Cl₂ / 0.08 h / 0 °C

2: acetonitrile / 0.08 h

3: 96 percent / NaOMe / methanol / Ambient temperature

4: 90 percent / 168 h / Ambient temperature; immobilized SP₄₀₉ nitrilase, aq. phosphate buffer

With pyridine; sodium methylate; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo00063a048

Reference yield:

: 142344-18-1,55735-66-5
ethyl 2,3-dideoxy-6-O-trityl-α-D-erythro-hex-2-enopyranoside

: 148379-83-3
Ethyl 2,3,6-trideoxy-α-D-erythro-hept-2-enopyranuronic acid

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / Ambient temperature

2: BF₃*Et₂O / ethanol; CH₂Cl₂ / Ambient temperature

3: pyridine / CH₂Cl₂ / 0.08 h / 0 °C

4: acetonitrile / 0.08 h

5: 96 percent / NaOMe / methanol / Ambient temperature

6: 90 percent / 168 h / Ambient temperature; immobilized SP₄₀₉ nitrilase, aq. phosphate buffer

With pyridine; boron trifluoride diethyl etherate; sodium methylate; In methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jo00063a048