ALCAFTADINE

Base Information

• Chemical Name: ALCAFTADINE
• CAS No.: 147084-10-4
• Molecular Formula: C19H21N3O
• Molecular Weight: 307.40
• Mol file: 147084-10-4.mol

Synonyms:R 89674;Lastacaft;UNII-7Z8O94ECSX;

Chemical Property of ALCAFTADINE

Chemical Property:

• Melting Point: 167 °C
• Boiling Point: 556.2±60.0 °C(Predicted)
• PKA: 8.76±0.20(Predicted)
• PSA: 38.13000
• Density: 1.24
• LogP: 2.71710
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

Alcaftadine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Alcaftadine, a histamine H1/H2 receptor antagonist, was approved in the United States in 2010 for the prevention of itching and redness associated with allergic conjunctivitis. Seasonal and perennial allergic conjunctivitis affects up to 40% of the population worldwide. There are numerous treatment options, with topical antihistamines being an effective therapy. Some of the primary symptoms and signs of allergic conjunctivitis are ocular itching and conjunctival redness. The pharmaceutical market for conjunctivitis is substantial and steadily increasing.
• Uses: Alcaftadine is a H1 histamine receptor antagonist. Alcaftadine is used to prevent eye irritation and treat the signs and symptoms of allergic conjunctivitis.
• Clinical Use: Alcaftadine, an ophthalmic histamine H1 receptor antagonist, was approved by the FDA for the prevention of itching associated with allergic conjunctivitis and was launched under the trade name Lastacaft in early 2011. Alcaftadine was discovered by Janssen Pharmaceuticals and marketed by Vistakon Pharmaceuticals, both subsidiaries of Johnson & Johnson. However, unlike other marketed drugs, the synthesis of alcaftadine was only mentioned in the patents filed by Janssen’s scientists approximately twenty years ago.