AC-TYR-VAL-ALA-ASP(OTBU)-ALDEHYDE-DIMETHYL ACETAL

Base Information

• Chemical Name: AC-TYR-VAL-ALA-ASP(OTBU)-ALDEHYDE-DIMETHYL ACETAL
• CAS No.: 147395-39-9
• Molecular Formula: C₂₉H₄₆N₄O₉
• Molecular Weight: 594.706
• Mol file: 147395-39-9.mol

Synonyms:L-Alaninamide,N-acetyl-L-tyrosyl-L-valyl-N-[1-(dimethoxymethyl)-3-(1,1-dimethylethoxy)-3-oxopropyl]-,(S)-

Chemical Property of AC-TYR-VAL-ALA-ASP(OTBU)-ALDEHYDE-DIMETHYL ACETAL

Chemical Property:

• PSA: 181.39000
• LogP: 2.48400
• Storage Temp.: -15°C

Purity/Quality:

AC-TYR-VAL-ALA-ASP(OTBU)-ALDEHYDEDIMETHYL ACETAL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AC-TYR-VAL-ALA-ASP(OTBU)-ALDEHYDE-DIMETHYL ACETAL

There total 20 articles about AC-TYR-VAL-ALA-ASP(OTBU)-ALDEHYDE-DIMETHYL ACETAL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(S)-3-amino-4,4-dimethoxybutanoic acid 1,1-dimethylethyl ester (147395-36-6) + (S)-2-((S)-2-((S)-2-acetamido-3-(4-hydroxyphenyl)propanamido)-3-methylbutanamido)propanoic acid (143382-04-1) → Ac-Tyr-Val-Ala-Asp(OtBu)-H dimethyl acetal (147395-39-9)

Guidance literature:

With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/(SICI)1522-2675(19991110)82:11<1960::AID-HLCA1960>3.0.CO;2-2

Reference yield: 70.0%

(S)-3-amino-4,4-dimethoxybutanoic acid 1,1-dimethylethyl ester (147395-36-6) + Ac-Tyr-Val-(R)-Ala-OH → Ac-Tyr-Val-(R)-Ala-Asp(OtBu)-H dimethyl acetal (147395-39-9)

Guidance literature:

With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/(SICI)1522-2675(19991110)82:11<1960::AID-HLCA1960>3.0.CO;2-2

Reference yield: 40.0%

(RS)-3-amino-4,4-dimethoxybutanoic acid 1,1-dimethylethyl ester (260051-91-0) + (S)-2-((S)-2-((S)-2-acetamido-3-(4-hydroxyphenyl)propanamido)-3-methylbutanamido)propanoic acid (143382-04-1) → Ac-Tyr-Val-Ala-(RS)-Asp(OtBu)-H dimethyl acetal (147395-39-9)

Guidance literature:

With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/(SICI)1522-2675(19991110)82:11<1960::AID-HLCA1960>3.0.CO;2-2

upstream raw materials:

(RS)-3-amino-4,4-dimethoxybutanoic acid 1,1-dimethylethyl ester

(S)-2-((S)-2-((S)-2-acetamido-3-(4-hydroxyphenyl)propanamido)-3-methylbutanamido)propanoic acid

N-[(phenylmethoxy)carbonyl]-D-aspartic acid,1,1-dimethylethyl ester

(RS)-4-oxo-3-{[(phenylmethoxy)carbonyl]amino}butanoic acid 1,1-dimethylethyl ester

Refernces