1-Pyrrolidinecarboxylic acid, 4-(acetylthio)-2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S,4S)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 4-(acetylthio)-2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S,4S)-
CAS No.:148017-42-9
Molecular Formula:C12H21 N O4 S
Molecular Weight:275.369
Hs Code.:
Mol file:148017-42-9.mol

Synonyms:1-Pyrrolidinecarboxylicacid, 4-(acetylthio)-2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S-cis)-(9CI)

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 4-(acetylthio)-2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S,4S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S,4S)-4-(acetylthio)-2-(hydroxymethyl)-1-Pyrrolidinecarboxylicacid1,1-dimethylethylester
10mg
$ 45.00

ChemScene
1-Pyrrolidinecarboxylicacid,4-(acetylthio)-2-(hydroxymethyl)-,1,1-dimethylethylester,(2S,4S)-
100mg
$ 106.00

American Custom Chemicals Corporation
(2S,4S)-1,1-DIMETHYLETHYL-4-(ACETYLTHIO)-2-(HYDROXYMETHYL)-1-PYRROLIDINECARBOXYLIC ACID ESTER 95.00%
5MG
$ 504.97

Total 6 raw suppliers

Chemical Property of 1-Pyrrolidinecarboxylic acid, 4-(acetylthio)-2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S,4S)-

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.534
Boiling Point:388.527°C at 760 mmHg
Flash Point:188.775°C
PSA：92.14000
Density:1.207g/cm³
LogP:1.57430

Purity/Quality:

NLT 98% ^*data from raw suppliers

(2S,4S)-4-(acetylthio)-2-(hydroxymethyl)-1-Pyrrolidinecarboxylicacid1,1-dimethylethylester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 4-(acetylthio)-2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S,4S)-

There total 5 articles about 1-Pyrrolidinecarboxylic acid, 4-(acetylthio)-2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1N-hydrochloric acid: 1N-hydrochloric acid

: (2R,4S)-1-t-butoxycarbonyl-4-methanesulfonyloxypyrrolidine-2-methanol

: 10387-40-3
potassium thioacetate

: 148017-42-9
(2S,4S)-4-acetylthio-1-t-butoxycarbonylpyrrolidine-2-methanol

Guidance literature:: In N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethyl acetate;

Reference yield: 86.0%

: 148017-07-6
(2S,4R)-N-tetr-butoxycarbonyl-4-methanesulfonyloxy-2-hydroxymethylpyrrolidine

: 10387-40-3
potassium thioacetate

: 148017-42-9
(2S,4S)-4-acetylthio-1-t-butoxycarbonylpyrrolidine-2-methanol

Guidance literature:: In N,N-dimethyl-formamide; at 65 ℃; for 3.75h;
DOI:10.7164/antibiotics.49.478

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 148017-42-9
(2S,4S)-4-acetylthio-1-t-butoxycarbonylpyrrolidine-2-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / NaOH / methanol / 3 h / Ambient temperature

2: 1.) ethyl chloroformate, triethylamine, 2.) sodium borohydride, tetra-n-butylammonium bromide / 1.) CH₂Cl₂, -40 deg C, 40 min, 2.) water, CH₂Cl₂, -10 deg C, 1 h

3: 86 percent / dimethylformamide / 3.75 h / 65 °C

With sodium hydroxide; sodium tetrahydroborate; tetrabutylammomium bromide; chloroformic acid ethyl ester; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.7164/antibiotics.49.478