Technology Process of 12(S)-HYDROXY-16-HEPTADECYNOIC ACID
There total 14 articles about 12(S)-HYDROXY-16-HEPTADECYNOIC ACID which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium salt of 1,3-diaminopropane;
for 24h;
DOI:10.1021/jm00062a014
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 94 percent / trimethylchlorosilane / hexane
2: 80 percent / pyridinium chlorochromate (PCC), molecular sieves / CH2Cl2 / 4 h
3: 74 percent / tetrahydrofuran / 0.5 h / -40 °C
4: 85 percent / N-methylmorpholine N-oxide, molecular sieves, tetrapropylammonium perruthenate / CH2Cl2 / 0.5 h
5: (S)-alpine-borane
6: aq. NaOH / tetrahydrofuran; methanol
7: potassium 3-aminopropylamide (KAPA) / 24 h
With
sodium hydroxide; chloro-trimethyl-silane; molecular sieve; tetrapropylammonium perruthennate; (-)-(S)-alpine-borane; potassium salt of 1,3-diaminopropane; 4-methylmorpholine N-oxide; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jm00062a014
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 80 percent / pyridinium chlorochromate (PCC), molecular sieves / CH2Cl2 / 4 h
2: 74 percent / tetrahydrofuran / 0.5 h / -40 °C
3: 85 percent / N-methylmorpholine N-oxide, molecular sieves, tetrapropylammonium perruthenate / CH2Cl2 / 0.5 h
4: (S)-alpine-borane
5: aq. NaOH / tetrahydrofuran; methanol
6: potassium 3-aminopropylamide (KAPA) / 24 h
With
sodium hydroxide; molecular sieve; tetrapropylammonium perruthennate; (-)-(S)-alpine-borane; potassium salt of 1,3-diaminopropane; 4-methylmorpholine N-oxide; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00062a014
