SECO RAPAMYCIN SODIUM SALT

Base Information

• Chemical Name: SECO RAPAMYCIN SODIUM SALT
• CAS No.: 148554-65-8
• Molecular Formula: C51H79 N O13 . Na
• Molecular Weight: 936.161
• Mol file: 148554-65-8.mol

Synonyms:SECO RAPAMYCIN SODIUM SALT

Chemical Property of SECO RAPAMYCIN SODIUM SALT

Chemical Property:

• Melting Point: 120-122°C
• PSA: 209.26000
• LogP: 5.10910
• Storage Temp.: Amber Vial, -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

85% ^*data from raw suppliers

(19E/Z)-secoRapamycinSodiumSalt(~80%byHPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Rapamycin is a natural macrolide immunosuppressant that activates mTORC1. Seco Rapamycin (sodium salt) is a nonenzyme-dependent degradation product of rapamycin resulting from ester hydration followed by dehydration. It has less than 4% of the potency of rapamycin in a thymocyte proliferation assay. Rapamycin quickly degrades to two ring-opened products, including seco rapamycin, in the cytoplasm or in homogenates of Caco-2 cells. Like rapamycin, seco rapamycin is secreted from cells by P-glycoprotein and metabolized to a common dihydro species. While seco rapamycin poorly activates mTOR, it mimics rapamycin in its ability to inhibit the proteasome.
• Uses: A metabolite of Sirolimus A decomposition product of Rapamycin (R124000).