Chemical Property of SECO RAPAMYCIN SODIUM SALT
Chemical Property:
- Melting Point:120-122°C
- PSA：209.26000
- LogP:5.10910
- Storage Temp.:Amber Vial, -20°C Freezer, Under Inert Atmosphere
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- Purity/Quality:
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97% *data from raw suppliers
(19E/Z)-secoRapamycinSodiumSalt(~80%byHPLC) *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Description
Rapamycin is a natural macrolide immunosuppressant that activates mTORC1. Seco Rapamycin (sodium salt) is a nonenzyme-dependent degradation product of rapamycin resulting from ester hydration followed by dehydration. It has less than 4% of the potency of rapamycin in a thymocyte proliferation assay. Rapamycin quickly degrades to two ring-opened products, including seco rapamycin, in the cytoplasm or in homogenates of Caco-2 cells. Like rapamycin, seco rapamycin is secreted from cells by P-glycoprotein and metabolized to a common dihydro species. While seco rapamycin poorly activates mTOR, it mimics rapamycin in its ability to inhibit the proteasome.
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Uses
A metabolite of Sirolimus A decomposition product of Rapamycin (R124000).
