GR 127935 hydrochloride

Base Information

• Chemical Name: GR 127935 hydrochloride
• CAS No.: 148642-42-6
• Molecular Formula: C29H31 N5 O3 . Cl H
• Molecular Weight: 0
• ChEMBL ID: CHEMBL1256656
• DSSTox Substance ID: DTXSID0042587
• Metabolomics Workbench ID: 63155
• Wikidata: Q27133036
• Mol file: 148642-42-6.mol

Synonyms:GR 127935 hydrochloride;148642-42-6;GR 127935 hydrochloride hydrate;GR127935 hydrochloride;GR127935 (hydrochloride);GR 127935 HCl;N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1'-biphenyl-4-carboxamide hydrochloride;CHEBI:64111;N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide hydrochloride;GR-127935 hydrochloride;MLS002153332;4-[2-methoxy-5-({[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl}amino)phenyl]-1-methylpiperazin-1-ium chloride;N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-carboxamide hydrate hydrochloride;SR-01000076115;SMR001230745;N-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide hydrochloride;GR127935hydrochloride;N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide;hydrochloride;EU-0100790;SCHEMBL6017123;CHEMBL1256656;DTXSID0042587;BCP19014;Tox21_500790;AKOS024456623;CCG-222094;LP00790;NCGC00094125-01;NCGC00261475-01;BG177433;HY-100794;E98769;G 5793;J-008498;SR-01000076115-1;SR-01000076115-3;Q27133036;GR 127935;GR-127935;N-(4-Methoxy-3-(4-methylpiperazin-1-yl)phenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride

Chemical Property of GR 127935 hydrochloride

Chemical Property:

• PSA: 83.73000
• LogP: 5.91100
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble10mg/mL, clear
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 533.2193676
• Heavy Atom Count: 38
• Complexity: 739

Purity/Quality:

97% ^*data from raw suppliers

GR127935Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C.Cl
• Description: GR127935 is an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1B, 5-HT1Dα, and 5-HT1Dβ (IC50s = 3.16, 1.26, and 0.13 nM, respectively). It is selective for the 5-HT1B and 5-HT1D receptors over other 5-HT receptors (IC50s = 39.81->10,000 nM in radioligand binding assays). GR127935 increases extracellular 5-HT levels in the guinea pig frontal cortex and prevents increases in 5-HT in rat frontal cortex induced by the selective serotonin reuptake inhibitor paroxetine . It enhances memory consolidation in an autoshaping learning task in rats when administered post-training at a dose of 10 mg/kg. It has been used to elucidate the 5-HT receptor subtypes involved in the anti-inflammatory activity of sumatriptan following myocardial ischemia-reperfusion injury and testicular torsion/detorsion.
• Uses: GR 127935 Hydrochloride is a selective and potent 5-HT1B/1D serotonin receptor antagonist.