Chemical Property of [(1S,2E,6E)-1-hydroxy-3,7,11-trimethyldodeca-2,6,10-trienyl]phosphonic acid
Chemical Property:
- PSA：87.57000
- LogP:3.90170
- Storage Temp.:−20°C
- XLogP3:3.1
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:8
- Exact Mass:302.16469634
- Heavy Atom Count:20
- Complexity:425
- Purity/Quality:
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≥98% *data from raw suppliers
α-hydroxy Farnesyl Phosphonic Acid ≥98% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:F,Xi
- Statements:
11-36/37/38
- Safety Statements:
16-26-36-7
- MSDS Files:
-
Useful:
- Canonical SMILES:CC(=CCCC(=CCCC(=CC(O)P(=O)(O)O)C)C)C
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Description
α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase). At concentrations greater than 1 μM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells.
