(2S)-2,3-Dihydroxy-N-methoxy-2,N-dimethyl-propionamide

Base Information

• Chemical Name: (2S)-2,3-Dihydroxy-N-methoxy-2,N-dimethyl-propionamide
• CAS No.: 149099-00-3
• Molecular Formula: C6H13 N O4
• Molecular Weight: 163.17
• Mol file: 149099-00-3.mol

Synonyms:Propanamide,2,3-dihydroxy-N-methoxy-N,2-dimethyl-, (S)-;(2S)-2,3-Dihydroxy-N-methoxy-N-methyl-2-methylpropanamide

Chemical Property of (2S)-2,3-Dihydroxy-N-methoxy-2,N-dimethyl-propionamide

Chemical Property:

• Vapor Pressure: 0.00113mmHg at 25°C
• Refractive Index: 1.487
• Boiling Point: 267.1°C at 760 mmHg
• PKA: 12.30±0.29(Predicted)
• Flash Point: 115.3°C
• PSA: 70.00000
• Density: 1.223g/cm³
• LogP: -1.25050
• Storage Temp.: -20°C Freezer
• Solubility.: Acetone, Dichloromethane, Chloroform (Soluble), Ethyl Acetate, Methanol (Sparing

Purity/Quality:

98%Min ^*data from raw suppliers

(2S)-2,3-Dihydroxy-N-methoxy-2,N-dimethyl-propionamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2S)-2,3-Dihydroxy-N-methoxy-2,N-dimethyl-propionamide (cas# 149099-00-3) is a compound useful in organic synthesis.

Technology Process of (2S)-2,3-Dihydroxy-N-methoxy-2,N-dimethyl-propionamide

There total 3 articles about (2S)-2,3-Dihydroxy-N-methoxy-2,N-dimethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Weinreb amide of 2-methyl-2-propeonic acid (132960-14-6) → (S)-2,3-dihydroxy-N-methoxy-2,N-dimethyl-propionamide (149099-00-3)

Guidance literature:

With AD-mix-β; methanesulfonamide; water; tert-butyl alcohol; at 0 - 20 ℃; for 26.0833h;

Reference yield:

Weinreb amide of 2-methyl-2-propeonic acid (132960-14-6) → (+)-(R)-2,3-dihydroxy-2,N-dimethyl-N-methoxy propanamide (356049-96-2) + (S)-2,3-dihydroxy-N-methoxy-2,N-dimethyl-propionamide (149099-00-3)

Guidance literature:

With methanesulfonamide; Modified-AD-mix-β^TM; In water; tert-butyl alcohol; at 0 ℃; Yield given;

DOI:10.1016/S0040-4039(00)60350-7

Reference yield:

methanesulfonamide (3144-09-0) + Weinreb amide of 2-methyl-2-propeonic acid (132960-14-6) → (+)-(R)-2,3-dihydroxy-2,N-dimethyl-N-methoxy propanamide (356049-96-2) + (S)-2,3-dihydroxy-N-methoxy-2,N-dimethyl-propionamide (149099-00-3)

Guidance literature:

With AD-mix-β; In water; tert-butyl alcohol; at 0 - 20 ℃; Overall yield = 92 %; Overall yield = 1.16 g;

DOI:10.1016/j.tetlet.2017.09.091

upstream raw materials:

Weinreb amide of 2-methyl-2-propeonic acid

methanesulfonamide

Downstream raw materials:

C₁₂H₁₇NO₄

C₂₀H₂₅NO₄

C₂₆H₂₉NO₄

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