2-Pyridineacetonitrile,3-fluoro-(9CI)

Base Information

• Chemical Name: 2-Pyridineacetonitrile,3-fluoro-(9CI)
• CAS No.: 149488-78-8
• Molecular Formula: C₇H₅FN₂
• Molecular Weight: 136.129
• Hs Code.: 2933399990
• Mol file: 149488-78-8.mol

Synonyms:2-Pyridineacetonitrile,3-fluoro-(9CI)

Chemical Property of 2-Pyridineacetonitrile,3-fluoro-(9CI)

Chemical Property:

• Vapor Pressure: 0.143mmHg at 25°C
• Refractive Index: 1.509
• Boiling Point: 216°C at 760 mmHg
• PKA: 0.75±0.22(Predicted)
• Flash Point: 84.5°C
• PSA: 36.68000
• Density: 1.203g/cm³
• LogP: 1.28678
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%min ^*data from raw suppliers

2-(3-Fluoropyridin-2-yl)acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridineacetonitrile,3-fluoro-(9CI)

There total 4 articles about 2-Pyridineacetonitrile,3-fluoro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-3-fluoropyridine (17282-04-1) + acetonitrile (75-05-8,26809-02-9) → 2-(3-fluoropyridin-2-yl)acetonitrile (149488-78-8)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; toluene; at 0 ℃; for 2h;

Reference yield:

tert-butyl 2-cyano-2-(3-fluoropyridin-2-yl)acetate (1404449-10-0) → 2-(3-fluoropyridin-2-yl)acetonitrile (149488-78-8)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; Reflux;

Reference yield:

2-chloromethyl-3-fluoropyridine hydrochloride (149463-07-0) → 2-(3-fluoropyridin-2-yl)acetonitrile (149488-78-8)

Guidance literature:

In methanol; water; ethyl acetate;

upstream raw materials:

2-chloromethyl-3-fluoropyridine hydrochloride

2-chloro-3-fluoropyridine

tert-butyl 2-cyano-2-(3-fluoropyridin-2-yl)acetate

acetonitrile

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK". . . Retrieved 2012/11/08.