2-(Chloromethyl)-3-fluoropyridine

Base Information

• Chemical Name: 2-(Chloromethyl)-3-fluoropyridine
• CAS No.: 149489-32-7
• Molecular Formula: C₆H₅ClFN
• Molecular Weight: 145.564
• Hs Code.: 2933399990
• European Community (EC) Number: 836-811-9
• DSSTox Substance ID: DTXSID70568763
• Wikidata: Q72454034
• Mol file: 149489-32-7.mol

Synonyms:2-(chloromethyl)-3-fluoropyridine;149489-32-7;2-Chloromethyl-3-fluoropyridine;PYRIDINE, 2-(CHLOROMETHYL)-3-FLUORO-;2-Chloromethyl-3-fluoro-pyridine;2-(Chloromethyl)3-fluoropyridine;MFCD11520697;2-(CHLOROMETHYL)-3-FLUORO-PYRIDINE;Pyridine,2-(chloromethyl)-3-fluoro-;Pyridine, 2-(chloromethyl)-3-fluoro- (9CI);SCHEMBL1878097;(chloromethyl)-3-fluoropyridine;AMY7984;DTXSID70568763;VACDDNDGSMRWPV-UHFFFAOYSA-N;AKOS006324732;PB14946;AC-33310;SY014099;P11154;EN300-1707828;A884270;J-506286

Chemical Property of 2-(Chloromethyl)-3-fluoropyridine

Chemical Property:

• Boiling Point: 173.2±25.0℃ (760 Torr)
• PKA: 1.29±0.22(Predicted)
• Flash Point: 58.5±23.2℃
• PSA: 12.89000
• Density: 1.270±0.06 g/cm3 (20 ºC 760 Torr)
• LogP: 1.95950
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 145.0094550
• Heavy Atom Count: 9
• Complexity: 89.1

Purity/Quality:

97% ^*data from raw suppliers

2-(Chloromethyl)-3-fluoropyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)CCl)F

Technology Process of 2-(Chloromethyl)-3-fluoropyridine

There total 3 articles about 2-(Chloromethyl)-3-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(3-fluoropyridin-2-yl)methanol (31181-79-0) → 2-(chloromethyl)-3-fluoropyridine (149489-32-7)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

2-acetoxymethyl-3-fluoro-pyridine (31181-71-2) → 2-(chloromethyl)-3-fluoropyridine (149489-32-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 2N aq. NaOH / methanol / 2 h / 25 °C

2: SOCl₂ / CH₂Cl₂ / 2 h / 25 °C

With sodium hydroxide; thionyl chloride; In methanol; dichloromethane;

DOI:10.1021/jm00081a004

Reference yield:

3-fluoro-2-methylpyridine 1-oxide (113209-81-7) → 2-(chloromethyl)-3-fluoropyridine (149489-32-7)

Guidance literature:

Multi-step reaction with 3 steps

1: AcOH / 120 °C

2: 2N aq. NaOH / methanol / 2 h / 25 °C

3: SOCl₂ / CH₂Cl₂ / 2 h / 25 °C

With sodium hydroxide; thionyl chloride; acetic acid; In methanol; dichloromethane;

DOI:10.1021/jm00081a004

upstream raw materials:

(3-fluoropyridin-2-yl)methanol

2-acetoxymethyl-3-fluoro-pyridine

3-fluoro-2-methylpyridine 1-oxide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 149489-32-7 Pyridine, 2-(chloromethyl)-3-fluoro- (9CI)

Send

Send

Metric Ton KG G Pound L ML

Send

Send