alpha-D-Ribofuranose,2-deoxy-2-fluoro-(9CI)

Base Information

• Chemical Name: alpha-D-Ribofuranose,2-deoxy-2-fluoro-(9CI)
• CAS No.: 149624-22-6
• Molecular Formula: C₅H₉FO₄
• Molecular Weight: 152.122
• Mol file: 149624-22-6.mol

Synonyms:alpha-D-Ribofuranose,2-deoxy-2-fluoro-(9CI)

Chemical Property of alpha-D-Ribofuranose,2-deoxy-2-fluoro-(9CI)

Chemical Property:

• Boiling Point: 365.7±42.0 °C(Predicted)
• PKA: 11.50±0.70(Predicted)
• PSA: 69.92000
• Density: 1.52±0.1 g/cm3(Predicted)
• LogP: -1.60510

Purity/Quality:

97% ^*data from raw suppliers

2-Deoxy-2-fluoro-α-D-ribofuranose ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of alpha-D-Ribofuranose,2-deoxy-2-fluoro-(9CI)

There total 4 articles about alpha-D-Ribofuranose,2-deoxy-2-fluoro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranose (491594-58-2) → 2-deoxy-2-fluoro-D-arabinofuranose (125155-47-7,125155-51-3,149624-22-6,172102-39-5)

Guidance literature:

With sodium hydroxide; at 20 ℃; for 0.05h;

DOI:10.1002/jlcr.3835

Reference yield:

C8H13FO4 → 2-deoxy-2-fluoro-D-arabinofuranose (125155-47-7,125155-51-3,149624-22-6,172102-39-5)

Guidance literature:

With hydrogenchloride; In water; for 0.5h;

DOI:10.1002/anie.201906805

Reference yield:

3-carbamoyl-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2yl)pyridin-1-ium (135339-76-3) → 2-deoxy-2-fluoro-D-arabinofuranose (125155-47-7,125155-51-3,149624-22-6,172102-39-5)

Guidance literature:

With potassium chloride; at 37 ℃; Rate constant; hydrolysis at various pH: 4 - 7.5;

DOI:10.1021/jo00017a004

upstream raw materials:

3-carbamoyl-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2yl)pyridin-1-ium

1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranose

Refernces

• 1、 Fang, Jason,Hait, Diptarka,Head-Gordon, Martin,Chang, Michelle C. Y.. "Chemoenzymatic Platform for Synthesis of Chiral Organofluorines Based on Type II Aldolases". supporting information. p. 11841 - 11845. Retrieved 2019/07/31.