1,3-Cyclohexanediol, 2-(hydroxymethyl)-2-methyl-, (1S,3S)- (9CI)

Base Information Edit

Chemical Name:1,3-Cyclohexanediol, 2-(hydroxymethyl)-2-methyl-, (1S,3S)- (9CI)
CAS No.:619335-74-9
Molecular Formula:C8H16O3
Molecular Weight:160.213
Hs Code.:
Mol file:619335-74-9.mol

Synonyms:1,3-Cyclohexanediol, 2-(hydroxymethyl)-2-methyl-, (1S,3S)- (9CI)

Suppliers and Price of 1,3-Cyclohexanediol, 2-(hydroxymethyl)-2-methyl-, (1S,3S)- (9CI)

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1,3-Cyclohexanediol, 2-(hydroxymethyl)-2-methyl-, (1S,3S)- (9CI) Edit

Chemical Property:

PSA：60.69000
LogP:-0.10930

Purity/Quality:: 99%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,3-Cyclohexanediol, 2-(hydroxymethyl)-2-methyl-, (1S,3S)- (9CI)

There total 12 articles about 1,3-Cyclohexanediol, 2-(hydroxymethyl)-2-methyl-, (1S,3S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 619335-63-6
(1S,3S)-2-benzyloxymethyl-2-methylcyclohexane-1,3-diol

: 619335-74-9
(1S,3S)-2-hydroxymethyl-2-methylcyclohexane-1,3-diol

Guidance literature:: With hydrogen; nickel; In methanol; at 20 ℃; for 10h;
DOI:10.1016/j.tetlet.2003.08.009

Reference yield:

: 82478-17-9
methyl 2,6-dimethoxy-1-methylcyclohexa-2,5-diene-1-carboxylate

: 619335-74-9
(1S,3S)-2-hydroxymethyl-2-methylcyclohexane-1,3-diol

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / LiAlH₄ / diethyl ether / 0.25 h / 0 °C

2: 92 percent / NaH; TBAI / tetrahydrofuran; dimethylformamide / 12 h / 20 °C

3: 95 percent / HCl / tetrahydrofuran / 0.5 h / 20 °C

4: 91 percent / (R)-CBS; BH₃*SMe₂ / CH₂Cl₂ / 10 h / 30 °C

5: Raney Ni; H₂ / methanol / 10 h / 20 °C / atmospheric pressure

With hydrogenchloride; lithium aluminium tetrahydride; dimethylsulfide borane complex; hydrogen; tetra-(n-butyl)ammonium iodide; nickel; sodium hydride; (R)-(+)-2-methyl-CBS-oxazaborolidine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo050349a

Reference yield:

: 619335-65-8
{[(2,6-dimethoxy-1-methylcyclohexa-2,5-dien-1-yl)methoxy]methyl}benzene

: 619335-74-9
(1S,3S)-2-hydroxymethyl-2-methylcyclohexane-1,3-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / HCl / tetrahydrofuran / 0.5 h / 20 °C

2: 91 percent / (R)-CBS; BH₃*SMe₂ / CH₂Cl₂ / 10 h / 30 °C

3: Raney Ni; H₂ / methanol / 10 h / 20 °C / atmospheric pressure

With hydrogenchloride; dimethylsulfide borane complex; hydrogen; nickel; (R)-(+)-2-methyl-CBS-oxazaborolidine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo050349a