3-(3-Fluorophenyl)-1H-pyrazole

Base Information

• Chemical Name: 3-(3-Fluorophenyl)-1H-pyrazole
• CAS No.: 149739-61-7
• Molecular Formula: C₉H₇FN₂
• Molecular Weight: 162.166
• Hs Code.: 2933199090
• European Community (EC) Number: 835-221-9
• Nikkaji Number: J880.978J
• Wikidata: Q27456558
• Mol file: 149739-61-7.mol

Synonyms:3-(3-Fluorophenyl)-1H-pyrazole;149739-61-7;5-(3-fluorophenyl)-1H-pyrazole;1H-Pyrazole,3-(3-fluorophenyl)-(9CI);3-(3-Fluorophenyl)pyrazole;3-fluoro phenylpyrazole;SCHEMBL5496649;MFCD09860580;AKOS009158555;TS-02161;EN300-344081;A1-01269;Q27456558;6TZ

Chemical Property of 3-(3-Fluorophenyl)-1H-pyrazole

Chemical Property:

• PSA: 28.68000
• LogP: 2.21580
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 162.05932639
• Heavy Atom Count: 12
• Complexity: 152

Purity/Quality:

99%+ ^*data from raw suppliers

3-(3-Fluorophenyl)-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)F)C2=CC=NN2

Technology Process of 3-(3-Fluorophenyl)-1H-pyrazole

There total 1 articles about 3-(3-Fluorophenyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Fluoro-3-iodobenzene (1121-86-4) + N-tosyl-N-propargylhydrazine (197093-16-6) → 3-(3-fluorophenyl)-1H-pyrazole (149739-61-7)

Guidance literature:

With copper(l) iodide; bis(triphenylphosphine) palladium (Il) acetate; potassium tert-butylate; triethylamine; palladium dichloride; Yield given. Multistep reaction; 1.) THF, room temp., 2.25 h, 2.) MeCN, reflux, 1.5 h, 3.) DMF, room temp., 1 h;

DOI:10.1055/s-1997-936

upstream raw materials:

1-Fluoro-3-iodobenzene

N-tosyl-N-propargylhydrazine