Benzamide, N-(6-amino-1,2,3,4-tetrahydro-2,4-dioxo-1,3-dipropyl-5-pyrimidinyl)-4-(trifluoromethyl)-

Base Information

• Chemical Name: Benzamide, N-(6-amino-1,2,3,4-tetrahydro-2,4-dioxo-1,3-dipropyl-5-pyrimidinyl)-4-(trifluoromethyl)-
• CAS No.: 149981-36-2
• Molecular Formula: C18H21 F3 N4 O3
• Molecular Weight: 398.38
• Mol file: 149981-36-2.mol

Synonyms:Benzamide, N-(6-amino-1,2,3,4-tetrahydro-2,4-dioxo-1,3-dipropyl-5-pyrimidinyl)-4-(trifluoromethyl)-

Chemical Property of Benzamide, N-(6-amino-1,2,3,4-tetrahydro-2,4-dioxo-1,3-dipropyl-5-pyrimidinyl)-4-(trifluoromethyl)-

Chemical Property:

• PKA: 10.77±0.20(Predicted)
• PSA: 99.12000
• Density: 1.37±0.1 g/cm3(Predicted)
• LogP: 3.33750

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzamide, N-(6-amino-1,2,3,4-tetrahydro-2,4-dioxo-1,3-dipropyl-5-pyrimidinyl)-4-(trifluoromethyl)-

There total 1 articles about Benzamide, N-(6-amino-1,2,3,4-tetrahydro-2,4-dioxo-1,3-dipropyl-5-pyrimidinyl)-4-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,3-dipropyl-5,6-diaminouracil (81250-34-2) + 4-trifluoromethyl-phenyl acetyl chloride (329-15-7) → 6-amino-5-<<4-(trifluoromethyl)benzoyl>amino>-1,3-di-n-propyluracil (149981-36-2)

Guidance literature:

With pyridine; Ambient temperature;

DOI:10.1021/jm00070a007

Reference yield: 78.0%

6-amino-5-<<4-(trifluoromethyl)benzoyl>amino>-1,3-di-n-propyluracil (149981-36-2) → 8-<4-(trifluoromethyl)phenyl>-1,3-di-n-propylxanthine (149981-17-9)

Guidance literature:

With sodium hydroxide; In ethanol; for 1h; Heating;

DOI:10.1021/jm00070a007

Reference yield:

6-amino-5-<<4-(trifluoromethyl)benzoyl>amino>-1,3-di-n-propyluracil (149981-36-2) → 7-allyl-8-<4-(trifluoromethyl)phenyl>-1,3-di-n-propylxanthine

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / 2 N aq. NaOH / ethanol / 1 h / Heating

2: 80 percent / K₂CO₃ / dimethylformamide / 3 h / Ambient temperature

With sodium hydroxide; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00070a007

upstream raw materials:

1,3-dipropyl-5,6-diaminouracil

4-trifluoromethyl-phenyl acetyl chloride

Downstream raw materials:

8-<4-(trifluoromethyl)phenyl>-1,3-di-n-propylxanthine