1H-Pyrazole-4-carboxylicacid,1-amino-,methylester(9CI)

Base Information

• Chemical Name: 1H-Pyrazole-4-carboxylicacid,1-amino-,methylester(9CI)
• CAS No.: 150017-46-2
• Molecular Formula: C₅H₇N₃O₂
• Molecular Weight: 141.129
• Mol file: 150017-46-2.mol

Synonyms:1H-Pyrazole-4-carboxylicacid,1-amino-,methylester(9CI)

Chemical Property of 1H-Pyrazole-4-carboxylicacid,1-amino-,methylester(9CI)

Chemical Property:

• Refractive Index: 1.599
• Boiling Point: 291.9±32.0 °C(Predicted)
• PKA: 2.09±0.10(Predicted)
• PSA: 0.00000
• Density: 1.41±0.1 g/cm3(Predicted)
• LogP: 0.00000
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

≥99% ^*data from raw suppliers

Methyl1-amino-1H-pyrazole-4-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrazole-4-carboxylicacid,1-amino-,methylester(9CI)

There total 2 articles about 1H-Pyrazole-4-carboxylicacid,1-amino-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl pyrazole-4-carboxylate (51105-90-9,54866-59-0) → methyl 1-amino-1H-pyrazole-4-carboxylate (150017-46-2)

Guidance literature:

methyl pyrazole-4-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.75h; Inert atmosphere;

With chloroamine; In diethyl ether; N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ja204856a

Reference yield:

methyl 1-trityl-1H-pyrazole-4-carboxylate (875554-08-8) → methyl 1-amino-1H-pyrazole-4-carboxylate (150017-46-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / methanol; dichloromethane; water / 3 h / 40 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; In methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/ja204856a

upstream raw materials:

methyl pyrazole-4-carboxylate

methyl 1-trityl-1H-pyrazole-4-carboxylate