Technology Process of Spiro[cyclohexane-1,2-[3]oxabicyclo[3.2.0]heptane], 1-ethoxy- (9CI)
There total 4 articles about Spiro[cyclohexane-1,2-[3]oxabicyclo[3.2.0]heptane], 1-ethoxy- (9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(I) triflate;
In
diethyl ether;
for 7h;
Irradiation;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) NaH, 2.) hexamethylphosphoramide / 1.) THF, reflux, 2 h, 2.) THF, reflux, 2 h
2: 63 percent / cuprous triflate / diethyl ether / 7 h / Irradiation
With
N,N,N,N,N,N-hexamethylphosphoric triamide; copper(I) triflate; sodium hydride;
In
diethyl ether;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) tert-butyl lithium / 1.) THF, pentane, -70 -> -10 deg C, 2.) THF, pentane, -70 -> 20 deg C
2: 1.) NaH, 2.) hexamethylphosphoramide / 1.) THF, reflux, 2 h, 2.) THF, reflux, 2 h
3: 63 percent / cuprous triflate / diethyl ether / 7 h / Irradiation
With
N,N,N,N,N,N-hexamethylphosphoric triamide; tert.-butyl lithium; copper(I) triflate; sodium hydride;
In
diethyl ether;