4-(Pyrrolidin-3-Yl)Pyridine

Base Information

• Chemical Name: 4-(Pyrrolidin-3-Yl)Pyridine
• CAS No.: 150281-47-3
• Molecular Formula: C9H12 N2
• Molecular Weight: 148.208
• Hs Code.: 2933990090
• European Community (EC) Number: 812-425-6
• DSSTox Substance ID: DTXSID50407328
• Mol file: 150281-47-3.mol

Synonyms:4-(Pyrrolidin-3-Yl)Pyridine;150281-47-3;4-pyrrolidin-3-ylpyridine;4-Pyrrolidin-3-yl-pyridine;4-(3-pyrrolidinyl)pyridine;3-(Pyridin-4-yl)pyrrolidine;4-Tetrahydro-1H-pyrrol-3-ylpyridine;PYRIDINE, 4-(3-PYRROLIDINYL)-;3-(4-pyridyl)pyrrolidine;4-(3-pyrrolidyl)pyridine;4 -(3-pyrrolidinyl)pyridine;4-(3-pyrrolidinyl) pyridine;SCHEMBL1189629;DTXSID50407328;HWJSDKNFWQDVIG-UHFFFAOYSA-N;4-(3-PYRROLIDINYL)-PYRIDINE;MFCD01862541;AKOS003655838;4-(pyrrolidin-3-yl)pyridine, AldrichCPR;BB 0221040;CS-0171016;FT-0645259;EN300-115754;A809026;J-513858;F2148-0160

Chemical Property of 4-(Pyrrolidin-3-Yl)Pyridine

Chemical Property:

• Vapor Pressure: 0.0121mmHg at 25°C
• Refractive Index: 1.536
• Boiling Point: 260.7°Cat760mmHg
• PKA: 9?+-.0.10(Predicted)
• Flash Point: 111.5°C
• PSA: 24.92000
• Density: 1.042g/cm³
• LogP: 1.48730
• Storage Temp.: 2-8°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 148.100048391
• Heavy Atom Count: 11
• Complexity: 119

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(Pyrrolidin-3-yl)pyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCC1C2=CC=NC=C2

Technology Process of 4-(Pyrrolidin-3-Yl)Pyridine

There total 1 articles about 4-(Pyrrolidin-3-Yl)Pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-(N-benzypyrrolidin-3-yl)pyridine (145105-06-2) → 4-pyrrolidin-3-yl-pyridine (150281-47-3)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; at 80 - 90 ℃; for 8h;

DOI:10.1007/s10593-007-0005-1

Reference yield: 83.8%

4-pyrrolidin-3-yl-pyridine (150281-47-3) + C47H50N4O2S2 → C57H62N6OS

Guidance literature:

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 80.0%

4-pyrrolidin-3-yl-pyridine (150281-47-3) + C25H33N3OS → 2-(1,1-dimethyl-2-oxo-2-pyrrolidin-1-ylethyl)-4-[1S-methyl-2-(3-{pyridin-4-yl} pyrrolidin-1-yl)carbonylamino-ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrole (667940-52-5)

Guidance literature:

C₂₅H₃₃N₃OS; With 4-Nitrophenyl chloroformate; triethylamine; In dichloromethane; at 20 ℃; for 1h;

4-pyrrolidin-3-yl-pyridine; for 2h;

upstream raw materials:

4-(N-benzypyrrolidin-3-yl)pyridine

Downstream raw materials:

4-(N-tert-butoxycarbonylpyrrolidin-3-yl)pyridine

ethyl (1E)-({2-[5-(1,1-dimethyl-2-oxo-2-pyrrolidin-1-ylethyl)-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl}amino)(3-pyridin-4-ylpyrrolidin-1-yl)methylidenecarbamate

isopropyl (1E)-({(2S)-2-[5-[2-(2-azabicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxoethyl]-2-(3,5-dimethylphenyl)-1H-indol-3-yl]propyl}amino)(3-pyridin-4-ylpyrrolidin-1-yl)methylenecarbamate

isopropyl (1E)-({2-[5-(1,1-dimethyl-2-oxo-2-(N,N-diethylamino)ethyl)-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl}amino)(3-pyridin-4-ylpyrrolidin-1-yl)methylidenecarbamate

Refernces

• 1、 -. "Rifamycin derivatives". Page/Page column 23. . Retrieved 2008/06/13.