6-MALEIMIDOCAPROIC ACID HYDRAZIDE, TRIFLUOROACETIC ACID

Base Information

• Chemical Name: 6-MALEIMIDOCAPROIC ACID HYDRAZIDE, TRIFLUOROACETIC ACID
• CAS No.: 151038-94-7
• Molecular Formula: C12H16F3N3O5
• Molecular Weight: 339.271
• Hs Code.: 2928000090
• Mol file: 151038-94-7.mol

Synonyms:6-MALEIMIDOCAPROIC ACID HYDRAZIDE, TRIFLUOROACETIC ACID;EMCH-TFA

Chemical Property of 6-MALEIMIDOCAPROIC ACID HYDRAZIDE, TRIFLUOROACETIC ACID

Chemical Property:

• Melting Point: 104-105°C
• PSA: 129.80000
• LogP: 1.12410
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO, Methanol

Purity/Quality:

97% ^*data from raw suppliers

6-Maleimidocaproic Acid Hydrazide, Trifluoroacetic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Maleimidocaproic Acid Hydrazide, Trifluoroacetic acid is a sulfhydryl and carbonyl reactive heterobifunctional crosslinking reagent. Useful for preparing immunoconjugates of doxorubicin. Spacer Arm: 11.8 Angstroms A sulfhydryl and carbonyl reactive heterobifunctional crosslinking reagent. Useful for preparing immunoconjugates of doxorubicin.Spacer Arm: 11.8 Angstroms

Technology Process of 6-MALEIMIDOCAPROIC ACID HYDRAZIDE, TRIFLUOROACETIC ACID

There total 2 articles about 6-MALEIMIDOCAPROIC ACID HYDRAZIDE, TRIFLUOROACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trifluoroacetic acid (76-05-1) + 2-[6-(2,5-Dioxo-1H-pyrrol-1-yl)-1-oxohexyl]hydrazinecarboxylic acid, 1,1-dimethylethyl ester (151038-95-8) → 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide trifluoroacetate (151038-94-7)

Guidance literature:

In dichloromethane; for 3h;

Reference yield:

2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-hexanoic acid (55750-53-3) + trifluoroacetic acid (76-05-1) → 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide trifluoroacetate (151038-94-7)

Guidance literature:

2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-hexanoic acid; With 4-methyl-morpholine; isobutyl chloroformate;

With t-butoxycarbonylhydrazine;

trifluoroacetic acid;

DOI:10.1016/j.jconrel.2014.06.039

Reference yield: 93.0%

6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide trifluoroacetate (151038-94-7) + ketotaxol (1053213-23-2) → C66H70N4O18

Guidance literature:

In ethanol; at 20 ℃; for 2h; Inert atmosphere; Darkness;

DOI:10.7554/eLife.25281

upstream raw materials:

trifluoroacetic acid

2-[6-(2,5-Dioxo-1H-pyrrol-1-yl)-1-oxohexyl]hydrazinecarboxylic acid, 1,1-dimethylethyl ester

2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-hexanoic acid

Downstream raw materials:

doxorubicin(6-maleimidocaproyl)hydrazone

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