2,2-Difluoroheptacosanoic acid, ethyl(ester)

Base Information

• Chemical Name: 2,2-Difluoroheptacosanoic acid, ethyl(ester)
• CAS No.: 151309-48-7
• Molecular Formula: C₁₆H₃₀F₂O₂
• Molecular Weight: 292.41
• Mol file: 151309-48-7.mol

Synonyms:2,2-Difluoroheptacosanoic acid, ethyl(ester)

Chemical Property of 2,2-Difluoroheptacosanoic acid, ethyl(ester)

Chemical Property:

• PSA: 26.30000
• LogP: 5.49580

Purity/Quality:

Ethyl2,2-difluorotetradecanoate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-Difluoroheptacosanoic acid, ethyl(ester)

There total 12 articles about 2,2-Difluoroheptacosanoic acid, ethyl(ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(E)-ethyl 2,2-difluorotetradec-3-enoate → ethyl 2,2-difluorotetradecanoate (151309-48-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; ethyl acetate; at 20 ℃; for 24h; Inert atmosphere;

Reference yield: 86.0%

1-dodecene (112-41-4,25067-08-7,62132-67-6) + Ethyl bromodifluoroacetate (667-27-6) → ethyl 2,2-difluorotetradecanoate (151309-48-7)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; fac-[Ir(ppy)3]; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

Reference yield: 86.0%

1-dodecene (112-41-4,25067-08-7,62132-67-6) + Ethyl bromodifluoroacetate (667-27-6) → (E)-ethyl 2,2-difluorotetradec-3-enoate + ethyl 2,2-difluorotetradecanoate (151309-48-7)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; fac-[Ir(ppy)3]; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 24h; Solvent; Reagent/catalyst; Inert atmosphere;

upstream raw materials:

2-oxo-tetradecanoic acid ethyl ester

1-dodecylbromide

2-carbethoxy-2-dodecyl-1,3-dithiane

1-dodecyne

Refernces

• 1、 -. "METHOD FOR PRODUCING DIFLUOROALKYLATED ORGANICS". Paragraph 0052; 0053; 0078; 0079. . Retrieved 2016/10/24.
• 2、 Yu, Chunghyeon,Iqbal, Naeem,Park, Sehyun,Cho, Eun Jin. "Selective difluoroalkylation of alkenes by using visible light photoredox catalysis". supporting information. p. 12884 - 12887. Retrieved 2014/12/11.