2-Pyridinecarboxamide,3-fluoro-(9CI)

Base Information

• Chemical Name: 2-Pyridinecarboxamide,3-fluoro-(9CI)
• CAS No.: 152126-32-4
• Molecular Formula: C₆H₅FN₂O
• Molecular Weight: 140.117
• Hs Code.: 2933399990
• Mol file: 152126-32-4.mol

Synonyms:3-Fluoropyridine-2-carboxamide

Chemical Property of 2-Pyridinecarboxamide,3-fluoro-(9CI)

Chemical Property:

• PSA: 55.98000
• LogP: 1.01990

Purity/Quality:

98%min ^*data from raw suppliers

3-Fluoropyridine-2-carboxamide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridinecarboxamide,3-fluoro-(9CI)

There total 3 articles about 2-Pyridinecarboxamide,3-fluoro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

lithium 3-fluoropyridine-2-carboxylate → 3-fluoropyridine-2-carboxamide (152126-32-4)

Guidance literature:

lithium 3-fluoropyridine-2-carboxylate; With oxalyl dichloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 5 ℃; for 2h;

With ammonia; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

3-fluoropyridine-2-carbonyl chloride (929568-98-9) → 3-fluoropyridine-2-carboxamide (152126-32-4)

Guidance literature:

With ammonia; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 - 25 ℃; for 1.75h; Inert atmosphere; Large scale;

DOI:10.1021/op0341420

Reference yield:

3-Fluoropyridine (372-47-4) → 3-fluoropyridine-2-carboxamide (152126-32-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / hexane; tert-butyl methyl ether / 4 h / -75 - -70 °C / Inert atmosphere

1.2: 1 h / -70 - 30 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 0 - 5 °C

With n-butyllithium; oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; tert-butyl methyl ether; N,N-dimethyl-formamide;

upstream raw materials:

3-Fluoropyridine

3-fluoropyridine-2-carbonyl chloride

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF PYRAZINONE THROMBIN INHIBITOR AND ITS INTERMEDIATES". . . Retrieved 2011/05/08.