Cyclopropanecarboxylic acid, 2-fluoro-, 1,1-dimethylethyl ester, (1R,2R)-rel-

Base Information

• Chemical Name: Cyclopropanecarboxylic acid, 2-fluoro-, 1,1-dimethylethyl ester, (1R,2R)-rel-
• CAS No.: 152237-14-4
• Molecular Formula: C₈H₁₃FO₂
• Molecular Weight: 160.188
• Mol file: 152237-14-4.mol

Synonyms:Cyclopropanecarboxylicacid, 2-fluoro-, 1,1-dimethylethyl ester, cis-

Chemical Property of Cyclopropanecarboxylic acid, 2-fluoro-, 1,1-dimethylethyl ester, (1R,2R)-rel-

Chemical Property:

• Boiling Point: 166.4±33.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.04±0.1 g/cm3(Predicted)
• LogP: 1.68610

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopropanecarboxylic acid, 2-fluoro-, 1,1-dimethylethyl ester, (1R,2R)-rel-

There total 11 articles about Cyclopropanecarboxylic acid, 2-fluoro-, 1,1-dimethylethyl ester, (1R,2R)-rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(1S,2R)-2-Benzenesulfinyl-2-fluoro-cyclopropanecarboxylic acid tert-butyl ester → tert-butyl cis-2-fluorocyclopropanecarboxylate (152237-14-4,152237-15-5)

Guidance literature:

With magnesium; mercury dichloride; In ethanol; Ambient temperature;

DOI:10.1016/0040-4039(96)01952-1

Reference yield:

1-chloro-2-fluorocyclopropanecarboxylic acid tert-butyl ester → tert-butyl 2-fluoro-cyclopropane-1-carboxylate (152237-14-4,152237-15-5) + tert-butyl cis-2-fluorocyclopropanecarboxylate (152237-14-4,152237-15-5)

Guidance literature:

1-chloro-2-fluorocyclopropanecarboxylic acid tert-butyl ester; With sodium tetrahydroborate; cobalt(II) chloride; In 1-methyl-pyrrolidin-2-one; at 0 - 50 ℃; for 1 - 3.5h;

With hydrogenchloride; In 1-methyl-pyrrolidin-2-one; water; at 40 ℃; Product distribution / selectivity;

Reference yield:

1-chloro-2-fluorocyclopropanecarboxylic acid tert-butyl ester → tert-butyl 2-fluoro-cyclopropane-1-carboxylate (152237-14-4,152237-15-5) + tert-butyl cis-2-fluorocyclopropanecarboxylate (152237-14-4,152237-15-5)

Guidance literature:

1-chloro-2-fluorocyclopropanecarboxylic acid tert-butyl ester; With sodium tetrahydroborate; cobalt(II) chloride; In 1-methyl-pyrrolidin-2-one; at 0 - 50 ℃; for 1 - 3.5h;

With hydrogenchloride; In 1-methyl-pyrrolidin-2-one; water; at 40 ℃; Product distribution / selectivity;

upstream raw materials:

tert-Butyl acrylate

Downstream raw materials:

(±)-cis-2-fluorocyclopropanecarboxylic acid

Refernces

• 1、 Shibue, Taku,Fukuda, Yasumichi. "Stereoselective synthesis of cis -2-fluorocyclopropanecarboxylic acid". . p. 7226 - 7231. Retrieved 2014/08/18.
• 2、 -. "PROCESS FOR REDUCTIVE DEHALOGENATION". Page/Page column 4-5. . Retrieved 2008/06/13.