4-(TRIFLUOROMETHOXY)CINNAMIC ALDEHYDE

Base Information

• Chemical Name: 4-(TRIFLUOROMETHOXY)CINNAMIC ALDEHYDE
• CAS No.: 681484-59-3
• Molecular Formula: C10H7F3O2
• Molecular Weight: 216.16
• Mol file: 681484-59-3.mol

Synonyms:

Chemical Property of 4-(TRIFLUOROMETHOXY)CINNAMIC ALDEHYDE

Chemical Property:

• PSA: 26.30000
• LogP: 2.79730

Purity/Quality:

99% ^*data from raw suppliers

4-(TRIFLUOROMETHOXY)CINNAMIC ALDEHYDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(TRIFLUOROMETHOXY)CINNAMIC ALDEHYDE

There total 4 articles about 4-(TRIFLUOROMETHOXY)CINNAMIC ALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3-(4-trifluoromethoxyphenyl)prop-2-en-1-ol (1129693-44-2) → 3-(4-trifluoromethoxyphenyl)propenal (681484-59-3)

Guidance literature:

With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 0 ℃; for 3h;

DOI:10.1021/jm801374t

Reference yield: 69.0%

p-trifluoromethoxybenzaldehyde (659-28-9) + (triphenylphosphoranylidene)acetaldehyde (2136-75-6) → 3-(4-trifluoromethoxyphenyl)propenal (681484-59-3)

Guidance literature:

In toluene; for 17h; Reflux;

Reference yield:

acrylaldehyde diethyl acetal (3054-95-3) → 3-(4-trifluoromethoxyphenyl)propenal (681484-59-3)

Guidance literature:

With potassium chloride; tetrabutylammonium acetate; palladium diacetate; potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 3h;

DOI:10.1002/cjoc.201800205

upstream raw materials:

3-(4-trifluoromethoxyphenyl)prop-2-en-1-ol

p-trifluoromethoxybenzaldehyde

(triphenylphosphoranylidene)acetaldehyde

acrylaldehyde diethyl acetal

Downstream raw materials:

5-(4-trifluoromethoxyphenyl)penta-2,4-dienoic acid ethyl ester

(E)-1-(buta-1,3-dien-1-yl)-4-trifluoromethoxybenzene

Refernces

• 1、 Qiao, Cuifang,Chen, Anrong,Gao, Bingjian,Liu, Yang,Huang, Hanmin. "Palladium-Catalyzed Cascade Double C—N Bond Activation: A New Strategy for Aminomethylation of 1,3-Dienes with Aminals". supporting information. p. 929 - 933. Retrieved 2018/09/22.
• 2、 Kim, Pilho,Kang, Sunhee,Boshoff, Helena I.,Jiricek, Jan,Collins, Margaret,Singh, Ramandeep,Manjunatha, Ujjini H.,Niyomrattanakit, Pornwaratt,Zhang, Liang,Goodwin, Michael,Dick, Thomas,Keller, Thomas H.,Dowd, Cynthia S.,Barry III, Clifton E.. "Structure-activity relationships of antitubercular nitroimidazoles. 2. determinants of aerobic activity and quantitative structure-activity relationships". experimental part. p. 1329 - 1344. Retrieved 2009/12/07.