1-Pyrrolidinepropanoic acid, -bta--oxo-2-thioxo-, methyl ester

Base Information

• Chemical Name: 1-Pyrrolidinepropanoic acid, -bta--oxo-2-thioxo-, methyl ester
• CAS No.: 152325-45-6
• Molecular Formula: C₈H₁₁NO₃S
• Molecular Weight: 201.246
• Mol file: 152325-45-6.mol

Synonyms:1-Pyrrolidinepropanoic acid, -bta--oxo-2-thioxo-, methyl ester

Chemical Property of 1-Pyrrolidinepropanoic acid, -bta--oxo-2-thioxo-, methyl ester

Chemical Property:

• PSA: 78.70000
• LogP: 0.43720

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Pyrrolidinepropanoic acid, -bta--oxo-2-thioxo-, methyl ester

There total 1 articles about 1-Pyrrolidinepropanoic acid, -bta--oxo-2-thioxo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

pyrrolidin-2-thione (2295-35-4) + 3-chloro-3-oxopropanoic acid methyl ester (37517-81-0) → 1-methylformylaceto-2-thiopyrrolidinone (152325-45-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.3987/COM-92-S29

Reference yield: 37.0%

1-methylformylaceto-2-thiopyrrolidinone (152325-45-6) → 1-(2-diazomethylformylaceto)-2-thiopyrrolidinone

Guidance literature:

With triethylamine; Methanesulfonyl azide; In dichloromethane; for 3h; Ambient temperature;

DOI:10.3987/COM-92-S29

Reference yield:

1-methylformylaceto-2-thiopyrrolidinone (152325-45-6) → methyl-4,9a-epithio-2,3,3a,4,5,9b-hexahydro-1,3,5-trioxo-2-phenyl-1H-pyrrolo<3,4-g>indolizine-4-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: 37 percent / mesyl azide, Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

2: 44 percent / rhodium(II) acetate / benzene / 0.5 h / 100 °C

With rhodium(II) acetate; triethylamine; Methanesulfonyl azide; In dichloromethane; benzene;

DOI:10.3987/COM-92-S29

upstream raw materials:

pyrrolidin-2-thione

3-chloro-3-oxopropanoic acid methyl ester

Refernces