2,6-Dichloro-5-fluoropyridin-3-amine

Base Information

Chemical Name:2,6-Dichloro-5-fluoropyridin-3-amine
CAS No.:152840-65-8
Molecular Formula:C₅H₃Cl₂FN₂
Molecular Weight:180.997
Hs Code.:2933399090
UNII:53SL35HDF2
DSSTox Substance ID:DTXSID60566399
Wikidata:Q82451993
Mol file:152840-65-8.mol

Synonyms:2,6-Dichloro-5-fluoropyridin-3-amine;152840-65-8;3-AMINO-2,6-DICHLORO-5-FLUOROPYRIDINE;2,6-DICHLORO-5-FLUORO-3-PYRIDINAMINE;5-Amino-2,6-dichloro-3-fluoropyridine;53SL35HDF2;MFCD11044255;3-PYRIDINAMINE, 2,6-DICHLORO-5-FLUORO-;2,6-DICHLORO-5-FLUOROPYRIDIN-3-AMINE HCL;UNII-53SL35HDF2;SCHEMBL8235252;DTXSID60566399;AKOS006307067;AB62906;AM62467;2,6-Dichloro-5-fluoro-pyridin-3-amine;AC-25143;DS-14302;SY060422;CS-0005626;5-AMINO-2,6-DICHLORO-3-FLUORO-PYRIDINE;EN300-1982054;A883870

Suppliers and Price of 2,6-Dichloro-5-fluoropyridin-3-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,6-Dichloro-5-fluoropyridin-3-amine
500mg
$ 130.00

SynQuest Laboratories
2,6-Dichloro-5-fluoropyridin-3-amine 98%
1 g
$ 159.00

SynQuest Laboratories
2,6-Dichloro-5-fluoropyridin-3-amine 98%
5 g
$ 476.00

Matrix Scientific
2,6-Dichloro-5-fluoropyridin-3-amine hydrochloride 95+%
1g
$ 1092.00

Matrix Scientific
2,6-Dichloro-5-fluoropyridin-3-amine hydrochloride 95+%
250mg
$ 492.00

Crysdot
2,6-Dichloro-5-fluoropyridin-3-amine 98%
5g
$ 312.00

Crysdot
2,6-Dichloro-5-fluoropyridin-3-amine 98%
10g
$ 505.00

Crysdot
2,6-Dichloro-5-fluoropyridin-3-amine 98%
25g
$ 950.00

Chemenu
3-Amino-2,6-dichloro-5-fluoropyridine 98%
25g
$ 898.00

Chemenu
3-Amino-2,6-dichloro-5-fluoropyridine 98%
10g
$ 477.00

Total 43 raw suppliers

Chemical Property of 2,6-Dichloro-5-fluoropyridin-3-amine

Chemical Property:

Boiling Point:295.7±35.0 °C(Predicted)
PKA:-1.02±0.10(Predicted)
PSA：38.91000
Density:1.601±0.06 g/cm3(Predicted)
LogP:2.69090
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:179.9657317
Heavy Atom Count:10
Complexity:124

Purity/Quality:

99%, ^*data from raw suppliers

2,6-Dichloro-5-fluoropyridin-3-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=NC(=C1F)Cl)Cl)N
Uses 2,6-Dichloro-5-fluoro-3-pyridinamine is mainly used in organic synthesis and pharmaceutical intermediates.

Technology Process of 2,6-Dichloro-5-fluoropyridin-3-amine

There total 1 articles about 2,6-Dichloro-5-fluoropyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 113237-20-0
2,6-dichloro-5-fluoropyridine-3-carboxamide

: 152840-65-8
2,6-dichloro-5-fluoropyridine-3-amine

Guidance literature:: With lead(IV) acetate; hydrogenchloride; Yield given. Multistep reaction; 1.) t-BuOH, 100 deg C, 3 h, 2.) Et₂O, 0 deg C, 4 h;
DOI:10.1002/hlca.19940770419

Reference yield:

: 152840-65-8
2,6-dichloro-5-fluoropyridine-3-amine

: 157402-71-6
N-benzyloxy-5-chloro-3-cyclopropyl-6-fluoro-3H-imidazo<4,5-b>pyridine-2-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) oxalyl chloride, 3.) K₂CO₃ / 1.) Et₂O, r.t., 6 h; 2.) Et₂O, 24 deg C, 16 h, 0 deg C, 1 h; 3.) DMF, 155-160 deg C, 48 h

2: 1.) LiN(Me₃Si)2 / 1.) -75 deg C, THF, 2 h; 2.) -75 deg C, 2 h, THF

3: 95 percent / NaCN, NH₃ / methanol / 1 h / 45 - 50 °C / 1.) 45-50 deg C, 1 h, 24 deg C, 95percent

4: 69 percent / ethanol; H₂O / 48 h / 73 °C

With oxalyl dichloride; sodium cyanide; ammonia; potassium carbonate; lithium hexamethyldisilazane; In methanol; ethanol; water;
DOI:10.1002/hlca.19940770419

Reference yield:

: 152840-65-8
2,6-dichloro-5-fluoropyridine-3-amine

: 157402-72-7
7-(benzyloxy)-2-chloro-10-cyclopropyl-3-fluoro-6,7,8,10-tetrahydropyrido<2',3':4,5>imidazo<1,2-c>pyrimidine-6,8-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) oxalyl chloride, 3.) K₂CO₃ / 1.) Et₂O, r.t., 6 h; 2.) Et₂O, 24 deg C, 16 h, 0 deg C, 1 h; 3.) DMF, 155-160 deg C, 48 h

2: 1.) LiN(Me₃Si)2 / 1.) -75 deg C, THF, 2 h; 2.) -75 deg C, 2 h, THF

3: 95 percent / NaCN, NH₃ / methanol / 1 h / 45 - 50 °C / 1.) 45-50 deg C, 1 h, 24 deg C, 95percent

4: 69 percent / ethanol; H₂O / 48 h / 73 °C

5: 85 percent / tetrahydrofuran / 1 h / 65 - 70 °C

With oxalyl dichloride; sodium cyanide; ammonia; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1002/hlca.19940770419