4-Pyrimidinecarboxylicacid,6-amino-2-formyl-,ethylester(9CI)

Base Information

Chemical Name:4-Pyrimidinecarboxylicacid,6-amino-2-formyl-,ethylester(9CI)
CAS No.:153093-62-0
Molecular Formula:C8H9 N3 O3
Molecular Weight:195.18
Hs Code.:
Mol file:153093-62-0.mol

Synonyms:4-Pyrimidinecarboxylicacid,6-amino-2-formyl-,ethylester(9CI)

Suppliers and Price of 4-Pyrimidinecarboxylicacid,6-amino-2-formyl-,ethylester(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 4-Pyrimidinecarboxylicacid,6-amino-2-formyl-,ethylester(9CI)

Chemical Property:

PSA：95.17000
LogP:0.62920

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Pyrimidinecarboxylicacid,6-amino-2-formyl-,ethylester(9CI)

There total 2 articles about 4-Pyrimidinecarboxylicacid,6-amino-2-formyl-,ethylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 138899-44-2
6-amino-4-(ethoxycarbonyl)-2-(hydroxymethyl)pyrimidine

: 153093-62-0
6-amino-4-(ethoxycarbonyl)pyrimidine-2-carboxaldehyde

Guidance literature:: With manganese(IV) oxide; In acetonitrile; at 82 ℃; for 3h;
DOI:10.1021/ja00080a010

Reference yield:

: 138899-43-1
6-amino-2,4-bis(ethoxycarbonyl)pyrimidine

: 153093-62-0
6-amino-4-(ethoxycarbonyl)pyrimidine-2-carboxaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / NaBH₄, t-BuOH / tetrahydrofuran / 18 h / -25 °C

2: 85 percent / MnO₂ / acetonitrile / 3 h / 82 °C

With manganese(IV) oxide; sodium tetrahydroborate; tert-butyl alcohol; In tetrahydrofuran; acetonitrile;
DOI:10.1021/ja00080a010

Reference yield:

: 153093-62-0
6-amino-4-(ethoxycarbonyl)pyrimidine-2-carboxaldehyde

: ethyl (R)-2-<1-<<(S)-2-<(tert-butyloxycarbonyl)amino>-2-carbamoylethyl>amino>-2-<((4S,5R)-4-methyl-5-phenyl-2-oxazolidinyl)carbonyl>-2-(R)-(methylthio)-1-ethyl>-6-aminopyrimidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 4 Angstroem molecular sieves / acetonitrile / 24 h / 25 °C

2: 1.) Sn(OTf)2, i-Pr₂NEt / 1.) THF, -20 deg C, 1 h, 2.) THF, -5 deg C, 11 h

With tin(II) trifluoromethanesulfonate; 4 A molecular sieve; N-ethyl-N,N-diisopropylamine; In acetonitrile;
DOI:10.1021/ja00080a010