THREO-DIHYDROBUPROPION

Base Information

• Chemical Name: THREO-DIHYDROBUPROPION
• CAS No.: 153365-82-3
• Molecular Formula: C₁₃H₂₀ClNO
• Molecular Weight: 241.761
• Mol file: 153365-82-3.mol

Synonyms:(R*,R*)-2-(T-BUTYLAMINO)1-(3-CHLOROPHENYL) PROPANOL;(R*,R*)-2-(T-BUTYLAMINO)1-(3-CHLOROPHENYL) PROPANOL MALEATE;THREO-HYDROBUPROPION;THREO-DIHYDROBUPROPION;threo-Hydroxy Bupropion HCl

Chemical Property of THREO-DIHYDROBUPROPION

Chemical Property:

• Boiling Point: 347.2±27.0 °C(Predicted)
• PKA: 13.67±0.20(Predicted)
• PSA: 32.26000
• Density: 1.078±0.06 g/cm3(Predicted)
• LogP: 3.54090

Purity/Quality:

97% ^*data from raw suppliers

racthreo-Dihydrobupropion ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of THREO-DIHYDROBUPROPION

There total 46 articles about THREO-DIHYDROBUPROPION which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bupropion (34841-39-9,34911-55-2,144445-75-0,144445-76-1) → (+)-(erythro)-2-tert-butylamino-1-(3-chlorophenyl)propan-1-ol (92264-82-9,153365-82-3) + (-)-(erythro)-2-tert-butylamino-1-(3-chlorophenyl)propan-1-ol (92264-82-9,153365-82-3) + (+)-(threo)-2-tert-butylamino-1-(3-chlorophenyl)propan-1-ol (92264-82-9,153365-82-3) + (-)-(threo)-2-tert-butylamino-1-(3-chlorophenyl)propan-1-ol (92264-82-9,153365-82-3)

Guidance literature:

bupropion; With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃; for 1h;

With hydrogenchloride; In ethanol; water; pH=1;

With potassium hydroxide; In ethanol; water; pH=7 - 11;

Reference yield:

bupropion (34841-39-9,34911-55-2,144445-75-0,144445-76-1) → (+)-(erythro)-2-tert-butylamino-1-(3-chlorophenyl)propan-1-ol (92264-82-9,153365-82-3) + (-)-(erythro)-2-tert-butylamino-1-(3-chlorophenyl)propan-1-ol (92264-82-9,153365-82-3) + (+)-(threo)-2-tert-butylamino-1-(3-chlorophenyl)propan-1-ol (92264-82-9,153365-82-3) + (-)-(threo)-2-tert-butylamino-1-(3-chlorophenyl)propan-1-ol (92264-82-9,153365-82-3)

Guidance literature:

bupropion; With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃; for 1h;

With hydrogenchloride; In ethanol; water; pH=1;

With potassium hydroxide; In ethanol; water; pH=7 - 11;

Reference yield:

bupropion (34841-39-9,34911-55-2,144445-75-0,144445-76-1) → (+)-(erythro)-2-tert-butylamino-1-(3-chlorophenyl)propan-1-ol (92264-82-9,153365-82-3) + (-)-(erythro)-2-tert-butylamino-1-(3-chlorophenyl)propan-1-ol (92264-82-9,153365-82-3) + (+)-(threo)-2-tert-butylamino-1-(3-chlorophenyl)propan-1-ol (92264-82-9,153365-82-3) + (-)-(threo)-2-tert-butylamino-1-(3-chlorophenyl)propan-1-ol (92264-82-9,153365-82-3)

Guidance literature:

bupropion; With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃; for 1h;

With hydrogenchloride; In ethanol; water; pH=1;

With potassium hydroxide; In ethanol; water; pH=7 - 11;

upstream raw materials:

Erythrohydrobupropion

3-chloro-benzonitrile

3'-chloro-propiophenone

bupropion