Technology Process of 1H-Pyrrole-2-acetic acid, 3-acetyl- (9CI)
There total 4 articles about 1H-Pyrrole-2-acetic acid, 3-acetyl- (9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
tetrahydrofuran; methanol; water;
1.) 0 deg C to r.t; 2.) 4 h, r.t.;
DOI:10.1016/S0040-4020(01)87212-4
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) oxalyl chloride / 1.) 1,2-dichloroethane, 15 min, r.t; 2.) 1,2-dichloroethane, 15 min, r.t.
2: 1.) aluminium chloride / 1.) 1,2-dichloroethane, 0 deg C to r.t, 10 min; 2.) 1,2-dichloroethane, nitromethane, 4 h, r.t; 0 deg C, 4 h
3: 96 percent / 5percent palladium on carbon / 1,3,5-trimethyl-benzene / 10 h / Heating
4: 88 percent / 2 M potassium hydroxide / tetrahydrofuran; methanol; H2O / 1.) 0 deg C to r.t; 2.) 4 h, r.t.
With
potassium hydroxide; aluminium trichloride; oxalyl dichloride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; water; 1,3,5-trimethyl-benzene;
DOI:10.1016/S0040-4020(01)87212-4
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 96 percent / 5percent palladium on carbon / 1,3,5-trimethyl-benzene / 10 h / Heating
2: 88 percent / 2 M potassium hydroxide / tetrahydrofuran; methanol; H2O / 1.) 0 deg C to r.t; 2.) 4 h, r.t.
With
potassium hydroxide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; water; 1,3,5-trimethyl-benzene;
DOI:10.1016/S0040-4020(01)87212-4
