[[6-HYDROXYMETHYL)-2-PYRIDINYL]METHYL]-CARBAMIC ACID, 1,1-DIMETHYLETHYL ESTER

Base Information

Chemical Name:[[6-HYDROXYMETHYL)-2-PYRIDINYL]METHYL]-CARBAMIC ACID, 1,1-DIMETHYLETHYL ESTER
CAS No.:153621-48-8
Molecular Formula:C12H18 N2 O3
Molecular Weight:238.28
Hs Code.:
Mol file:153621-48-8.mol

Synonyms:Carbamicacid, [[6-(hydroxymethyl)-2-pyridinyl]methyl]-, 1,1-dimethylethyl ester (9CI);tert-Butyl (6-hydroxymethylpyridin-2-ylmethyl)carbamate

Suppliers and Price of [[6-HYDROXYMETHYL)-2-PYRIDINYL]METHYL]-CARBAMIC ACID, 1,1-DIMETHYLETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
TERT-BUTYL-(6-(HYDROXYMETHYL)PYRIDIN-2-YL)METHYLCARBAMATE 98.00%
0.5G
$ 1540.00

Total 4 raw suppliers

Chemical Property of [[6-HYDROXYMETHYL)-2-PYRIDINYL]METHYL]-CARBAMIC ACID, 1,1-DIMETHYLETHYL ESTER

Chemical Property:

Vapor Pressure:6.66E-07mmHg at 25°C
Refractive Index:1.53
Boiling Point:393.7°C at 760 mmHg
PKA:11.34±0.46(Predicted)
Flash Point:191.9°C
PSA：71.45000
Density:1.147g/cm³
LogP:1.98950

Purity/Quality:

98%min ^*data from raw suppliers

TERT-BUTYL-(6-(HYDROXYMETHYL)PYRIDIN-2-YL)METHYLCARBAMATE 98.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of [[6-HYDROXYMETHYL)-2-PYRIDINYL]METHYL]-CARBAMIC ACID, 1,1-DIMETHYLETHYL ESTER

There total 5 articles about [[6-HYDROXYMETHYL)-2-PYRIDINYL]METHYL]-CARBAMIC ACID, 1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 50501-31-0
6-(Aminomethyl)-2-(hydroxymethyl)pyridine

: 153621-48-8
tert-butyl N-[(6-hydroxymethyl-2-pyridyl)methyl]carbamate

Guidance literature:: In dichloromethane; at 20 ℃; for 4h;
DOI:10.1134/S1070363217040107

Reference yield:

: 1190947-26-2
2-[(6-methyl-2-pyridyl)methyl]isoindoline-1,3-dione

: 153621-48-8
tert-butyl N-[(6-hydroxymethyl-2-pyridyl)methyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 20 °C

2: trifluoroacetic anhydride / tetrahydrofuran / 3 h / 20 °C

3: hydrazine hydrate / ethanol / 4 h / Reflux

4: dichloromethane / 4 h / 20 °C

With hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1134/S1070363217040107

Reference yield:

: 6-methyl-2-(1,3-dioxoisoindolin-2-yl)methylpyridine-1-oxide

: 153621-48-8
tert-butyl N-[(6-hydroxymethyl-2-pyridyl)methyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic anhydride / tetrahydrofuran / 3 h / 20 °C

2: hydrazine hydrate / ethanol / 4 h / Reflux

3: dichloromethane / 4 h / 20 °C

With hydrazine hydrate; trifluoroacetic anhydride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1134/S1070363217040107