4-AZEPAN-1-YL-BENZYLAMINE

Base Information

• Chemical Name: 4-AZEPAN-1-YL-BENZYLAMINE
• CAS No.: 581812-79-5
• Molecular Formula: C13H20N2
• Molecular Weight: 204.31
• Mol file: 581812-79-5.mol

Synonyms:4-AZEPAN-1-YL-BENZYLAMINE;AKOS B033643

Chemical Property of 4-AZEPAN-1-YL-BENZYLAMINE

Chemical Property:

• Boiling Point: 358.5±25.0 °C(Predicted)
• PKA: 10.43±0.10(Predicted)
• PSA: 29.26000
• Density: 1.024±0.06 g/cm3(Predicted)
• LogP: 3.29100

Purity/Quality:

99% ^*data from raw suppliers

4-Azepan-1-yl-benzylamine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AZEPAN-1-YL-BENZYLAMINE

There total 3 articles about 4-AZEPAN-1-YL-BENZYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(Hexahydroazepin-1-yl)benzonitrile (162377-67-5) → (4-(azepan-1-yl)phenyl)methanamine (581812-79-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h; Heating;

DOI:10.1021/jm070276i

Reference yield:

hexamethylene imine (111-49-9) → (4-(azepan-1-yl)phenyl)methanamine (581812-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / dimethylsulfoxide / 4 h / 120 °C

2: 100 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1021/jm070276i

Reference yield:

4-fluorobenzonitrile (1194-02-1,143234-87-1) → (4-(azepan-1-yl)phenyl)methanamine (581812-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / dimethylsulfoxide / 4 h / 120 °C

2: 100 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1021/jm070276i

upstream raw materials:

4-(Hexahydroazepin-1-yl)benzonitrile

hexamethylene imine

4-fluorobenzonitrile

Downstream raw materials:

N-(5-(3-(4-(azepan-1-yl)benzyl)ureido)isoquinolin-3-yl)acetamide

2,2,2-trichloro-N-(isoquinolin-5-yl)acetamide

N-[4-(1-azepanyl)benzyl]-2-(5-isoquinolinyl)propanamide

N-(4-(azepan-1-yl)benzyl)-7-chloro-2-ethylimidazo[1,2-a]pyridine-3-carboxamide