3-Amino-cyclohexanol

Base Information

• Chemical Name: 3-Amino-cyclohexanol
• CAS No.: 6982-42-9
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.175
• Hs Code.: 2922199090
• Mol file: 6982-42-9.mol

Synonyms:Cyclohexanol,3-amino-, cis- (8CI);cis-3-Aminocyclohexanol;cis-3-Hydroxycyclohexylamine;

Chemical Property of 3-Amino-cyclohexanol

Chemical Property:

• Boiling Point: 128 °C(Press: 18 Torr)
• PKA: 15.09±0.40(Predicted)
• PSA: 46.25000
• Density: 1.037±0.06 g/cm3(Predicted)
• LogP: 0.94890

Purity/Quality:

98%Min ^*data from raw suppliers

rac-cis-3-Aminocyclohexanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-cyclohexanol

There total 11 articles about 3-Amino-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-cyclohex-2-enone (5220-49-5) → (+/-)-trans-3-aminocyclohexanol (6850-39-1,6982-42-9,40525-77-7) + (+/-)-cis-3-aminocyclohexanol (6850-39-1,6982-42-9,40525-77-7)

Guidance literature:

With sodium; In tetrahydrofuran; isopropyl alcohol; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

Reference yield:

3-amino-cyclohex-2-enone (5220-49-5) → (+/-)-trans-3-aminocyclohexanol (6850-39-1,6982-42-9,40525-77-7) + (+/-)-cis-3-aminocyclohexanol (6850-39-1,6982-42-9,40525-77-7)

Guidance literature:

With sodium; In tetrahydrofuran; isopropyl alcohol; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

Reference yield:

(+/-)-cis-2-(3-hydroxycyclohexyl)isoindole-1,3-dione (106729-79-7,123132-92-3) → (+/-)-cis-3-aminocyclohexanol (6850-39-1,6982-42-9,40525-77-7)

Guidance literature:

With hydrazine hydrate; In methanol; Heating;

DOI:10.1016/j.tetasy.2004.05.035

upstream raw materials:

(rac)-trans-1-(3-hydroxycyclohexyl)benzamide

3-amino-cyclohex-2-enone

(+/-)-cis-2-(3-hydroxycyclohexyl)isoindole-1,3-dione

m-Hydroxyaniline

Downstream raw materials:

cis-3-N,N-dimethylaminocyclohexanol

(+/-)-trans-1-acetoxy-3-acetylamino-cyclohexane

cis-3-acetamidocyclohexyl acetate

(+/-)-N-(cis-3-hydroxy-cyclohexyl)-N'-phenyl-urea

Refernces

• 1、 Levy, Laura M.,De Gonzalo, Gonzalo,Gotor, Vicente. "Resolution of N-protected cis- and trans-3-aminocyclohexanols via lipase-catalyzed enantioselective acylation in organic media". . p. 2051 - 2056. Retrieved 2007/10/03.