β-Methyl-4-nitrohydrocinnamic acid methyl ester

Base Information

• Chemical Name: β-Methyl-4-nitrohydrocinnamic acid methyl ester
• CAS No.: 24254-61-3
• Molecular Formula: C11H13 N O4
• Molecular Weight: 223.23
• Hs Code.: 2916399090
• Mol file: 24254-61-3.mol

Synonyms:Hydrocinnamicacid, b-methyl-p-nitro-, methyl ester(8CI)

Chemical Property of β-Methyl-4-nitrohydrocinnamic acid methyl ester

Chemical Property:

• Vapor Pressure: 0.000274mmHg at 25°C
• Boiling Point: 322.7°C at 760 mmHg
• Flash Point: 135.9°C
• PSA: 72.12000
• Density: 1.188g/cm³
• LogP: 2.78460

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of β-Methyl-4-nitrohydrocinnamic acid methyl ester

There total 1 articles about β-Methyl-4-nitrohydrocinnamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ methyl 3-(4-nitrophenyl)butyrate (24254-61-3)

Guidance literature:

Reference yield:

methyl 3-(4-nitrophenyl)butyrate (24254-61-3) → 3-<4-Amino-phenyl>-buttersaeure-methylester (6555-06-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 14h; under 3102.97 Torr;

DOI:10.1021/jm020054e

Reference yield:

methyl 3-(4-nitrophenyl)butyrate (24254-61-3) → 3-(4-{2-[4-(3-o-tolyl-ureido)-phenyl]-acetylamino}-phenyl)-butyric acid methyl ester (1025909-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol / 14 h / 3102.97 Torr

2: HATU; DIEA / dimethylformamide / 2 h

With hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm020054e

Downstream raw materials:

3-<4-Amino-phenyl>-buttersaeure-methylester

3-(4-{2-[4-(3-o-tolyl-ureido)-phenyl]-acetylamino}-phenyl)-butyric acid

3-(4-{2-[4-(3-o-tolyl-ureido)-phenyl]-acetylamino}-phenyl)-butyric acid methyl ester

Refernces