4-Amino-4-(3-bromo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-Amino-4-(3-bromo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:669068-74-0
Molecular Formula:C17H25FN2O2
Molecular Weight:308.396
Hs Code.:
Mol file:669068-74-0.mol

Synonyms:4-Amino-4-(3-bromo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Suppliers and Price of 4-Amino-4-(3-bromo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
4-Amino-4-(3-bromo-phenyl)-piperidine-1-carboxylicacidtert-butylester 95
10g
$ 4200.00

Labseeker
4-Amino-4-(3-bromo-phenyl)-piperidine-1-carboxylicacidtert-butylester 95
5g
$ 2750.00

Total 2 raw suppliers

Chemical Property of 4-Amino-4-(3-bromo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

PSA：55.56000
LogP:4.27220

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

4-Amino-4-(3-bromo-phenyl)-piperidine-1-carboxylicacidtert-butylester 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 4-Amino-4-(3-bromo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

There total 5 articles about 4-Amino-4-(3-bromo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 256951-79-8
4-(4-fluorophenyl)-tert-butoxycarbonylpiperidine-4-carbonitrile

: 669068-74-0
tert-butyl 4-(aminomethyl)-4-(4-fluorophenyl)piperidine-1-carboxylate

Guidance literature:: With ammonia; hydrogen; nickel; In ethanol; at 20 ℃; for 24h; under 2585.81 Torr;

Reference yield:

: 459-22-3
4-fluorophenylacetonitrile

: 669068-74-0
tert-butyl 4-(aminomethyl)-4-(4-fluorophenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Bu₄N⁽¹⁺⁾*HSO₄^(1-) / aq. NaOH

2.1: 1-chloroethylchloroformate / 1,2-dichloro-ethane / 85 °C

2.2: aq. NaOH / methanol

3.1: BH₃-THF / 40 °C

With borane-THF; carbonochloridic acid 1-chloro-ethyl ester; tetra(n-butyl)ammonium hydrogensulfate; In sodium hydroxide; 1,2-dichloro-ethane;
DOI:10.1016/j.tetlet.2006.05.082

Reference yield:

: 55-86-7
mechlorethamine hydrochloride

: 669068-74-0
tert-butyl 4-(aminomethyl)-4-(4-fluorophenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Bu₄N⁽¹⁺⁾*HSO₄^(1-) / aq. NaOH

2.1: 1-chloroethylchloroformate / 1,2-dichloro-ethane / 85 °C

2.2: aq. NaOH / methanol

3.1: BH₃-THF / 40 °C

With borane-THF; carbonochloridic acid 1-chloro-ethyl ester; tetra(n-butyl)ammonium hydrogensulfate; In sodium hydroxide; 1,2-dichloro-ethane;
DOI:10.1016/j.tetlet.2006.05.082