Cyclopropanamine, 2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-, (1R,2R)-rel- (9CI)

Base Information

• Chemical Name: Cyclopropanamine, 2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-, (1R,2R)-rel- (9CI)
• CAS No.: 669087-52-9
• Molecular Formula: C10H19NO2
• Molecular Weight: 185.26

Synonyms:Cyclopropanamine, 2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-, (1R,2R)-rel- (9CI)

Chemical Property of Cyclopropanamine, 2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-, (1R,2R)-rel- (9CI)

Chemical Property:

• Boiling Point: 276.4±25.0 °C(Predicted)
• PKA: 8.97±0.40(Predicted)
• Density: 1.06±0.1 g/cm3(Predicted)

Purity/Quality:

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Technology Process of Cyclopropanamine, 2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-, (1R,2R)-rel- (9CI)

There total 8 articles about Cyclopropanamine, 2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-, (1R,2R)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl (1RS,2SR)-trans-2-[2-(tetrahydro-2H-2-pyranyloxy)ethyl]-1-cyclopropylcarbamate → (1RS,2SR)-trans-2-[2-(tetrahydro-2H-2-pyranyloxy)ethyl]-1-cyclopropylamine (669087-52-9)

Guidance literature:

With potassium hydroxide; In methanol; for 48h; Heating;

DOI:10.1515/znb-2003-0906

Reference yield: 83.0%

methyl (1RS,2RS)-cis-2-[2-(tetrahydro-2H-2-pyranyloxy)ethyl]-1-cyclopropylcarbamate → (1RS,2RS)-cis-2-[2-(tetrahydro-2H-2-pyranyloxy)ethyl]-1-cyclopropylamine (669087-52-9)

Guidance literature:

With potassium hydroxide; In methanol; for 48h; Heating;

DOI:10.1515/znb-2003-0906

Reference yield:

2-[2-(tetrahydro-2H-2-pyranyloxy)ethyl]-1-cyclopropane carboxylic acid → (1RS,2SR)-trans-2-[2-(tetrahydro-2H-2-pyranyloxy)ethyl]-1-cyclopropylamine (669087-52-9)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / tetrahydrofuran / 1 h / -5 °C

2: 2.03 g / NH₃ / tetrahydrofuran / 3 h / 0 - 20 °C

3: 95 percent / KOH / 2 h / 5 - 20 °C

4: 93 percent / aq. KOH / methanol / 48 h / Heating

With potassium hydroxide; ammonia; triethylamine; In tetrahydrofuran; methanol; 3: Hofmann degradation;

DOI:10.1515/znb-2003-0906

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