3-BROMO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-OL

Base Information

• Chemical Name: 3-BROMO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-OL
• CAS No.: 54738-73-7
• Molecular Formula: C5H3BrN4O
• Molecular Weight: 215.009
• Hs Code.: 2933990090
• Mol file: 54738-73-7.mol

Synonyms:3-Bromo-4-hydroxypyrazolo[3,4-d]pyrimidine;3-Bromoallopurinol;NSC 344532;3-Bromo-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one;

Chemical Property of 3-BROMO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-OL

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 350℃
• Refractive Index: 1.834
• Boiling Point: 473.096 °C at 760 mmHg
• PKA: 8.16±0.70(Predicted)
• Flash Point: 239.92 °C
• PSA: 74.43000
• Density: 2.236 g/cm³
• LogP: 0.40870
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

3-Bromo-1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-OL

There total 5 articles about 3-BROMO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Allopurinol (315-30-0) → 3-bromo-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (54738-73-7)

Guidance literature:

With bromine; In water; at 90 ℃; Reflux;

DOI:10.1021/acs.jmedchem.1c00135

Reference yield:

4-chloro-1H-pyrazolo[3,4-d]pyrimidine (5399-92-8) → 3-bromo-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (54738-73-7)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 0 - 20 ℃;

Reference yield:

4-hydroxypyrazolo(3,4-d)pyrimidine (315-30-0) → (IIa) (54738-73-7)

Guidance literature:

With bromine; In water;

upstream raw materials:

4-hydroxypyrazolo(3,4-d)pyrimidine

4-chloro-1H-pyrazolo[3,4-d]pyrimidine

Allopurinol

Downstream raw materials:

3-bromo-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-pyrazolo<3,4-d>pyrimidin-4(5H)-one

3-phenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

Refernces

• 1、 Bouton, Jakob,Ferreira De Almeida Fiuza, Ludmila,Cardoso Santos, Camila,Mazzarella, Maria Angela,De Nazaré Correia Soeiro, Maria,Maes, Louis,Karalic, Izet,Caljon, Guy,Van Calenbergh, Serge. "Revisiting Pyrazolo[3,4- d]pyrimidine Nucleosides as Anti- Trypanosoma cruzi and Antileishmanial Agents". . p. 4206 - 4238. Retrieved 2021/05/04.
• 2、 -. "Pyrazolopyrimidines as therapeutic agents". . . Retrieved 2008/06/13.