2-Cyclopentene-1-carboxylicacid,2-acetyl-1-amino-3-methyl-,methylester,

Base Information

Chemical Name:2-Cyclopentene-1-carboxylicacid,2-acetyl-1-amino-3-methyl-,methylester,
CAS No.:669060-26-8
Molecular Formula:C₁₀H₁₅NO₃
Molecular Weight:197.234
Hs Code.:
Mol file:669060-26-8.mol

Synonyms:2-Cyclopentene-1-carboxylicacid,2-acetyl-1-amino-3-methyl-,methylester,

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Chemical Property of 2-Cyclopentene-1-carboxylicacid,2-acetyl-1-amino-3-methyl-,methylester,

Chemical Property:

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Technology Process of 2-Cyclopentene-1-carboxylicacid,2-acetyl-1-amino-3-methyl-,methylester,

There total 5 articles about 2-Cyclopentene-1-carboxylicacid,2-acetyl-1-amino-3-methyl-,methylester, which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 669060-20-2
(5S,8R)-1-(8-isopropyl-7,10-dimethoxy-2-methyl-6,9-diazaspiro[4.5]deca-2,6,9-trien-1-yl)ethanone

: 669060-26-8
(1S)-2-acetyl-1-amino-3-methylcyclopent-2-enecarboxylic acid methyl ester

: (1'S,2R)-2-[(2-acetyl-1-amino-3-methylcyclopent-2-enecarbonyl)amino]-3-methylbutyric acid methyl ester

Guidance literature:: With water; trifluoroacetic acid; In acetonitrile; at 20 ℃; for 72h;
DOI:10.1016/j.tetasy.2003.10.013

Reference yield:

: 188177-79-9
(2R,5S)-5-(But-3-enyl)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine

: 669060-26-8
(1S)-2-acetyl-1-amino-3-methylcyclopent-2-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 62 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 78 percent / Dess-Martin reagent / CH₂Cl₂ / 1 h / 20 °C

3.1: 75 percent / copper(I) chloride; palladium dichloride; O₂ / H₂O; dimethylformamide / 10 h / 20 °C

4.1: 38 percent / caesium carbonate / acetonitrile / 4 h / Heating

5.1: 51 percent / trifluoroacetic acid; H₂O / acetonitrile / 72 h / 20 °C

With n-butyllithium; water; oxygen; caesium carbonate; Dess-Martin periodane; trifluoroacetic acid; copper(l) chloride; palladium dichloride; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 3.1: Wacker oxidation;
DOI:10.1016/j.tetasy.2003.10.013

Reference yield:

: 669060-09-7
(2'S,5'R)-1-[2-(3-butenyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl]propan-2-one

: 669060-26-8
(1S)-2-acetyl-1-amino-3-methylcyclopent-2-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / copper(I) chloride; palladium dichloride; O₂ / H₂O; dimethylformamide / 10 h / 20 °C

2: 38 percent / caesium carbonate / acetonitrile / 4 h / Heating

3: 51 percent / trifluoroacetic acid; H₂O / acetonitrile / 72 h / 20 °C

With water; oxygen; caesium carbonate; trifluoroacetic acid; copper(l) chloride; palladium dichloride; In water; N,N-dimethyl-formamide; acetonitrile; 1: Wacker oxidation;
DOI:10.1016/j.tetasy.2003.10.013