H2N-L-PRO-OME

Base Information

• Chemical Name: H2N-L-PRO-OME
• CAS No.: 604003-91-0
• Molecular Formula: C6H12N2O2
• Molecular Weight: 144.17
• Mol file: 604003-91-0.mol

Synonyms:N-ALPHA-AMINO-L-PROLINE METHYL ESTER;H2N-L-PRO-OME;L-Proline, 1-amino-, methyl ester (9CI)

Chemical Property of H2N-L-PRO-OME

Chemical Property:

• PSA: 55.56000
• LogP: 0.13570

Purity/Quality:

98.5% ^*data from raw suppliers

H2N-L-PRO-METHOXIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H2N-L-PRO-OME

There total 5 articles about H2N-L-PRO-OME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

(S)-1-nitrosopyrrolidine-2-carboxylic acid methyl ester (71922-04-8,35909-01-4) → (S)-1-aminopyrrolidine-2-carboxylic acid methyl ester (604003-91-0)

Guidance literature:

With acetic acid; zinc; In water; at 0 ℃; for 0.25h;

DOI:10.1021/jo800719j

Reference yield:

H-(N2-Boc)aPro-OMe → (S)-1-aminopyrrolidine-2-carboxylic acid methyl ester (604003-91-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.5h;

DOI:10.1016/S0960-894X(03)00393-7

Reference yield:

L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → (S)-1-aminopyrrolidine-2-carboxylic acid methyl ester (604003-91-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium nitrite; sulfuric acid / water / 0.17 h / 20 °C

2: sulfuric acid / 20 °C

3: zinc; acetic acid / 0.25 h / 0 °C

With sulfuric acid; acetic acid; zinc; sodium nitrite; In water;

DOI:10.1021/acs.orglett.7b03666

upstream raw materials:

(S)-1-tert-butoxycarbonylaminopyrrolidine-2-carboxylic acid

(S)-1-nitrosopyrrolidine-2-carboxylic acid methyl ester

nitrosoproline

L-proline