Technology Process of Cyclopenta[c]pyran-3(1H)-one, hexahydro-7a-methyl-, (4aR,7aR)-rel- (9CI)
There total 6 articles about Cyclopenta[c]pyran-3(1H)-one, hexahydro-7a-methyl-, (4aR,7aR)-rel- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
at 20 ℃;
for 20h;
atmospheric pressure;
DOI:10.1016/j.tet.2007.02.027
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 49 percent / BF3*Et2O / CH2Cl2 / 2 h / 0 °C
2: 30 percent / LiAlH(O-t-Bu)3 / diethyl ether; tetrahydrofuran / -78 °C
3: 82 percent / DMAP; dicyclohexylcarbodiimide / CH2Cl2 / 3 h / 20 °C
4: 70 percent / LiBr; Et3N / tetrahydrofuran / 20 °C
5: 98 percent / H2 / Pd/C / ethyl acetate / 20 h / 20 °C / atmospheric pressure
With
dmap; boron trifluoride diethyl etherate; hydrogen; lithium tri-t-butoxyaluminum hydride; triethylamine; dicyclohexyl-carbodiimide; lithium bromide;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate;
4: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.tet.2007.02.027
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 82 percent / DMAP; dicyclohexylcarbodiimide / CH2Cl2 / 3 h / 20 °C
2: 70 percent / LiBr; Et3N / tetrahydrofuran / 20 °C
3: 98 percent / H2 / Pd/C / ethyl acetate / 20 h / 20 °C / atmospheric pressure
With
dmap; hydrogen; triethylamine; dicyclohexyl-carbodiimide; lithium bromide;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
2: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.tet.2007.02.027
