Cyclobutanecarboxylic acid, 1-amino-2-(hydroxymethyl)-, (1S,2S)- (9CI)

Base Information

• Chemical Name: Cyclobutanecarboxylic acid, 1-amino-2-(hydroxymethyl)-, (1S,2S)- (9CI)
• CAS No.: 601501-24-0
• Molecular Formula: C6H11NO3
• Molecular Weight: 145.15644
• Mol file: 601501-24-0.mol

Synonyms:Cyclobutanecarboxylic acid, 1-amino-2-(hydroxymethyl)-, (1S,2S)- (9CI)

Chemical Property of Cyclobutanecarboxylic acid, 1-amino-2-(hydroxymethyl)-, (1S,2S)- (9CI)

Chemical Property:

• PSA: 83.55000
• LogP: -0.12890

Purity/Quality:

(1S,2S)-1-amino-2-(hydroxymethyl)cyclobutane-1-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclobutanecarboxylic acid, 1-amino-2-(hydroxymethyl)-, (1S,2S)- (9CI)

There total 22 articles about Cyclobutanecarboxylic acid, 1-amino-2-(hydroxymethyl)-, (1S,2S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(1S,4R,7S)-7-tert-butyl-1-(hydroxymethyl)-6-metoxy-7-methyl-8-oxa-5-azaspiro[3.5]non-5-en-9-one (601501-21-7) → (1R,2S)-1-amino-2-(hydroxymethyl)-cyclobutanecarbocylic acid (601501-24-0,601501-25-1,601501-27-3)

Guidance literature:

(1S,4R,7S)-7-tert-butyl-1-(hydroxymethyl)-6-metoxy-7-methyl-8-oxa-5-azaspiro[3.5]non-5-en-9-one; With trifluoroacetic acid; In water; acetonitrile; at 60 ℃; for 48h;

With sodium hydroxide; at 60 ℃; for 24h; Further stages.; ion exchange chromatography on Dowex 50W*8;

DOI:10.1002/ejoc.200200673

Reference yield: 76.0%

(1R,4R,7S)-7-tert-butyl-1-(hydroxymethyl)-6-metoxy-7-methyl-8-oxa-5-azaspiro[3.5]non-5-en-9-one (601501-20-6) → (1R,2R)-1-amino-2-(hydroxymethyl)-cyclobutanecarbocylic acid (601501-24-0,601501-25-1,601501-27-3)

Guidance literature:

(1R,4R,7S)-7-tert-butyl-1-(hydroxymethyl)-6-metoxy-7-methyl-8-oxa-5-azaspiro[3.5]non-5-en-9-one; With trifluoroacetic acid; In water; acetonitrile; at 60 ℃; for 48h;

With sodium hydroxide; In methanol; at 60 ℃; for 24h; Further stages.; ion exchange chromatography on Dowex 50W*8;

DOI:10.1002/ejoc.200200673

Reference yield: 76.0%

(1R,4S,7R)-7-tert-butyl-1-(hydroxymethyl)-6-metoxy-7-methyl-8-oxa-5-azaspiro[3.5]non-5-en-9-one (601501-17-1) → (1S,2R)-1-amino-2-(hydroxymethyl)-cyclobutanecarbocylic acid (601501-24-0,601501-25-1,601501-27-3)

Guidance literature:

(1R,4S,7R)-7-tert-butyl-1-(hydroxymethyl)-6-metoxy-7-methyl-8-oxa-5-azaspiro[3.5]non-5-en-9-one; With trifluoroacetic acid; In water; acetonitrile; at 60 ℃; for 48h;

With sodium hydroxide; In methanol; at 60 ℃; for 24h; Further stages.; ion exchange chromatography on Dowex 50W*8;

DOI:10.1002/ejoc.200200673

upstream raw materials:

(1R,4S,7R)-7-tert-butyl-1-(hydroxymethyl)-6-metoxy-7-methyl-8-oxa-5-azaspiro[3.5]non-5-en-9-one

(1S,4S,7R)-7-tert-butyl-1-(hydroxymethyl)-6-metoxy-7-methyl-8-oxa-5-azaspiro[3.5]non-5-en-9-one

(1R,4R,7S)-7-tert-butyl-1-(hydroxymethyl)-6-metoxy-7-methyl-8-oxa-5-azaspiro[3.5]non-5-en-9-one

(1S,4R,7S)-7-tert-butyl-1-(hydroxymethyl)-6-metoxy-7-methyl-8-oxa-5-azaspiro[3.5]non-5-en-9-one

Refernces