N-butyl-2-[(7-methyl-3-oxo-1,4-benzoxazin-4-yl)methyl]-1,3-thiazole-4-carboxamide

Base Information

Chemical Name:N-butyl-2-[(7-methyl-3-oxo-1,4-benzoxazin-4-yl)methyl]-1,3-thiazole-4-carboxamide
CAS No.:5973-21-7
Molecular Formula:C₁₇H₁₆N₂O₂
Molecular Weight:280.326
Hs Code.:
DSSTox Substance ID:DTXSID60412327
Wikidata:Q82219636

Synonyms:5973-21-7;N-butyl-2-[(7-methyl-3-oxo-1,4-benzoxazin-4-yl)methyl]-1,3-thiazole-4-carboxamide;DTXSID60412327

Suppliers and Price of N-butyl-2-[(7-methyl-3-oxo-1,4-benzoxazin-4-yl)methyl]-1,3-thiazole-4-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of N-butyl-2-[(7-methyl-3-oxo-1,4-benzoxazin-4-yl)methyl]-1,3-thiazole-4-carboxamide

Chemical Property:

Vapor Pressure:8.98E-18mmHg at 25°C
Boiling Point:669.2°C at 760 mmHg
Flash Point:358.5°C
Density:1.274g/cm³
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:359.13036271
Heavy Atom Count:25
Complexity:490

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCNC(=O)C1=CSC(=N1)CN2C(=O)COC3=C2C=CC(=C3)C

Technology Process of N-butyl-2-[(7-methyl-3-oxo-1,4-benzoxazin-4-yl)methyl]-1,3-thiazole-4-carboxamide

There total 2 articles about N-butyl-2-[(7-methyl-3-oxo-1,4-benzoxazin-4-yl)methyl]-1,3-thiazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 3415-35-8
4-methyl-3H-1,4-benzodiazepine-2,5-(1H,4H)-dione

: 5973-21-7
1-benzyl-4-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 140 ℃; for 0.333333h; microwave;
DOI:10.1016/j.tetlet.2005.09.096

Reference yield:

: 5973-21-7
1-benzyl-4-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Guidance literature:

Reference yield: 75.0%

: 925-90-6
ethylmagnesium bromide

: 5973-21-7
1-benzyl-4-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

: C₁₉H₂₀N₂O

: 1-benzyl-2-ethyl-2-hydroxy-4-methyl-1,2,3,4-tetrahydro-benzo[e][1,4]diazepin-5-one

Guidance literature:: With methyltriisopropoxytitanium(IV); In tetrahydrofuran; at 20 ℃; for 16h; Further Variations:; reactant and reagent ratios; Product distribution;
DOI:10.1016/j.tetlet.2005.09.096