2H-1,4-Benzoxazin-3(4H)-one, 2,4-dihydroxy-7-methoxy-, (2S)- (9CI)

Base Information

• Chemical Name: 2H-1,4-Benzoxazin-3(4H)-one, 2,4-dihydroxy-7-methoxy-, (2S)- (9CI)
• CAS No.: 588716-65-8
• Molecular Formula: C9H9NO5
• Molecular Weight: 211.17146
• Mol file: 588716-65-8.mol

Synonyms:2H-1,4-Benzoxazin-3(4H)-one, 2,4-dihydroxy-7-methoxy-, (2S)- (9CI)

Chemical Property of 2H-1,4-Benzoxazin-3(4H)-one, 2,4-dihydroxy-7-methoxy-, (2S)- (9CI)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-1,4-Benzoxazin-3(4H)-one, 2,4-dihydroxy-7-methoxy-, (2S)- (9CI)

There total 13 articles about 2H-1,4-Benzoxazin-3(4H)-one, 2,4-dihydroxy-7-methoxy-, (2S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-Hydroxy-7-methoxy-2-methoxymethoxy-4H-benzo[1,4]oxazin-3-one → 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one (15893-52-4,147802-15-1,147802-16-2,588716-65-8)

Guidance literature:

With boron trichloride; In dichloromethane; at -40 - -5 ℃; for 1h;

DOI:10.1080/00032719808006490

Reference yield: 75.0%

4-hydroxy-7-methoxy-2,3-dioxo-1,4-benzoxazine (151253-61-1) → 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one (15893-52-4,147802-15-1,147802-16-2,588716-65-8)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 - 0 ℃; for 2h;

DOI:10.1055/s-1993-25936

Reference yield: 30.0%

4-Hydroxy-2,7-dimethoxy-2H-1,4-benzoxazin-3(4H)-one (55544-90-6,147802-07-1,147802-08-2) → 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one (15893-52-4,147802-15-1,147802-16-2,588716-65-8)

Guidance literature:

4-Hydroxy-2,7-dimethoxy-2H-1,4-benzoxazin-3(4H)-one; With boron trichloride; In dichloromethane; at 20 ℃; for 2.5h;

With silver carbonate; In tetrahydrofuran; water; for 0.333333h;

DOI:10.3797/scipharm.aut-05-08

upstream raw materials:

N-(2-hydroxy-4-methoxy-phenyl)-glyoxylohydroxamic acid

4-Hydroxy-2,7-dimethoxy-2H-1,4-benzoxazin-3(4H)-one

4-hydroxy-7-methoxy-2,3-dioxo-1,4-benzoxazine

2,2-Di-tert-butyl-7-methoxy-1,3,4,5-tetraoxa-9b-aza-2-sila-cyclopenta[a]cyclopropa[b]naphthalene

Downstream raw materials:

N-(2-hydroxy-4-methoxy-phenyl)-glyoxylohydroxamic acid