2-(1,3-Benzodioxol-5-yloxy)acetohydrazide

Base Information

• Chemical Name: 2-(1,3-Benzodioxol-5-yloxy)acetohydrazide
• CAS No.: 588680-00-6
• Molecular Formula: C9H10N2O4
• Molecular Weight: 210.189
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID50396708
• Wikidata: Q82197565
• Mol file: 588680-00-6.mol

Synonyms:2-(1,3-benzodioxol-5-yloxy)acetohydrazide;588680-00-6;2-(Benzo[d][1,3]dioxol-5-yloxy)acetohydrazide;2-(2H-1,3-benzodioxol-5-yloxy)acetohydrazide;Oprea1_337913;DTXSID50396708;BBL015229;MFCD03423116;STK261893;AKOS000305343;SB85997;VS-04858;CS-0315799;5-(N,N-DIMETHYL)-AMILORIDEHYDROCHLORIDE

Chemical Property of 2-(1,3-Benzodioxol-5-yloxy)acetohydrazide

Chemical Property:

• Vapor Pressure: 1.98E-08mmHg at 25°C
• Refractive Index: 1.59
• Boiling Point: 454°C at 760 mmHg
• Flash Point: 228.3°C
• PSA: 82.81000
• Density: 1.394g/cm³
• LogP: 0.87520
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 210.06405680
• Heavy Atom Count: 15
• Complexity: 236

Purity/Quality:

98%min ^*data from raw suppliers

2-(1,3-benzodioxol-5-yloxy)acetohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1OC2=C(O1)C=C(C=C2)OCC(=O)NN

Technology Process of 2-(1,3-Benzodioxol-5-yloxy)acetohydrazide

There total 3 articles about 2-(1,3-Benzodioxol-5-yloxy)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethyl 2-(benzo[d][1,3]dioxol-5-yloxy)acetate (179110-57-7) → (benzo[1,3]dioxol-5-yloxy)acetic acid hydrazide (588680-00-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Reflux;

DOI:10.2174/1573406416666201106111110

Reference yield:

Sesamol (533-31-3) → (benzo[1,3]dioxol-5-yloxy)acetic acid hydrazide (588680-00-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / potassium carbonate / dimethylformamide / 20 h / 20 °C

2: 80 percent / hydrazine monohydrate / ethanol; H₂O / 0.08 h / 20 °C

With potassium carbonate; hydrazine hydrate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2006.07.046

Reference yield:

piperonal (120-57-0,30024-74-9) → (benzo[1,3]dioxol-5-yloxy)acetic acid hydrazide (588680-00-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: H₂O₂; formic acid / CH₂Cl₂; H₂O / 18 h / Heating

1.2: 77 percent / NaOH / CH₂Cl₂; H₂O / 0.25 h / 20 °C

2.1: 85 percent / potassium carbonate / dimethylformamide / 20 h / 20 °C

3.1: 80 percent / hydrazine monohydrate / ethanol; H₂O / 0.08 h / 20 °C

With formic acid; dihydrogen peroxide; potassium carbonate; hydrazine hydrate; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2006.07.046

upstream raw materials:

ethyl 2-(benzo[d][1,3]dioxol-5-yloxy)acetate

Sesamol

piperonal