Pyrrolidine, 1-ethyl-3-(1-methylethyl)- (9CI)

Base Information

• Chemical Name: Pyrrolidine, 1-ethyl-3-(1-methylethyl)- (9CI)
• CAS No.: 588672-49-5
• Molecular Formula: C9H19N
• Molecular Weight: 141.25386
• Mol file: 588672-49-5.mol

Synonyms:Pyrrolidine, 1-ethyl-3-(1-methylethyl)- (9CI)

Chemical Property of Pyrrolidine, 1-ethyl-3-(1-methylethyl)- (9CI)

Chemical Property:

• Boiling Point: 163.7±8.0 °C(Predicted)
• PKA: 10.58±0.40(Predicted)
• PSA: 0.00000
• Density: 0.833±0.06 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pyrrolidine, 1-ethyl-3-(1-methylethyl)- (9CI)

There total 3 articles about Pyrrolidine, 1-ethyl-3-(1-methylethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-ethyl-3-(1-methylethyl)pyrrolidine-2,5-dione (185760-08-1) → 1-ethyl-3-(1-methylethyl)pyrrolidine (588672-49-5)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; for 3h; Heating;

DOI:10.1016/S0040-4020(03)00508-8

Reference yield: 53.0%

1-Ethyl-3-isopropylidene-pyrrolidine-2,5-dione (164026-32-8) → 1-ethyl-3-(1-methylethyl)pyrrolidine (588672-49-5)

Guidance literature:

With C₃₁H₃₅P; palladium diacetate; lithium tert-butoxide; In toluene; at 20 - 110 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1021/ja308950d

Reference yield:

1-Ethyl-3-isopropylidene-pyrrolidine-2,5-dione (164026-32-8) → 1-ethyl-3-(1-methylethyl)pyrrolidine (588672-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / hydrogen / 10 percent Pd/C / ethyl acetate / 5 h / 20 °C / 1520 Torr

2: 70 percent / BH₃*Me₂S / tetrahydrofuran / 3 h / Heating

With dimethylsulfide borane complex; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;

DOI:10.1016/S0040-4020(03)00508-8

upstream raw materials:

1-ethyl-3-(1-methylethyl)pyrrolidine-2,5-dione

1-Ethyl-3-isopropylidene-pyrrolidine-2,5-dione