Cyclobutanecarboxamide, 1-amino-2-(1-methylethyl)-, (1R,2R)- (9CI)

Base Information

Chemical Name:Cyclobutanecarboxamide, 1-amino-2-(1-methylethyl)-, (1R,2R)- (9CI)
CAS No.:587829-76-3
Molecular Formula:C8H16N2O
Molecular Weight:156.22544
Hs Code.:
Mol file:587829-76-3.mol

Synonyms:Cyclobutanecarboxamide, 1-amino-2-(1-methylethyl)-, (1R,2R)- (9CI)

Suppliers and Price of Cyclobutanecarboxamide, 1-amino-2-(1-methylethyl)-, (1R,2R)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclobutanecarboxamide, 1-amino-2-(1-methylethyl)-, (1R,2R)- (9CI)

Chemical Property:

Melting Point:44.9 °C
Boiling Point:300.4±21.0 °C(Predicted)
PKA:16.13±0.40(Predicted)
PSA：69.11000
Density:1.059±0.06 g/cm3(Predicted)
LogP:1.63580

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of Cyclobutanecarboxamide, 1-amino-2-(1-methylethyl)-, (1R,2R)- (9CI)

There total 3 articles about Cyclobutanecarboxamide, 1-amino-2-(1-methylethyl)-, (1R,2R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 587829-73-0
(1R,2R,1'S)-1-[(1'-methylbenzyl)amino]-2-iso-propylcyclobutanecarboxamide

: 587829-76-3
(1R,2R)-1-amino-2-isopropylcyclobutanecarboxamide

Guidance literature:: With hydrogen; palladium dihydroxide; In ethanol; acetic acid; at 20 ℃; for 4h; under 760 Torr;
DOI:10.1016/S0957-4166(03)00073-9

Reference yield:

: 27608-63-5
(+/-)-2-isopropylcyclobutanone

: 587829-76-3
(1R,2R)-1-amino-2-isopropylcyclobutanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 140 mg / AcOH / dimethylsulfoxide / 96 h / 55 - 60 °C

2: 85 percent / conc. H₂SO₄ / CH₂Cl₂ / 0 - 20 °C

3: 95 percent / H₂ / 20 percent Pd(OH)2/C / ethanol; acetic acid / 4 h / 20 °C / 760 Torr

With sulfuric acid; hydrogen; acetic acid; palladium dihydroxide; In ethanol; dichloromethane; acetic acid; dimethyl sulfoxide; 1: asymmetric Strecker reaction;
DOI:10.1016/S0957-4166(03)00073-9

Reference yield:

: 587829-69-4
(1R,2R,1'S)-1-[(1'-methylbenzyl)amino]-2-iso-propylcyclobutanecarbonitrile

: 587829-76-3
(1R,2R)-1-amino-2-isopropylcyclobutanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / conc. H₂SO₄ / CH₂Cl₂ / 0 - 20 °C

2: 95 percent / H₂ / 20 percent Pd(OH)2/C / ethanol; acetic acid / 4 h / 20 °C / 760 Torr

With sulfuric acid; hydrogen; palladium dihydroxide; In ethanol; dichloromethane; acetic acid;
DOI:10.1016/S0957-4166(03)00073-9