Technology Process of Cyclobutanecarboxamide, 1-amino-2-(1-methylethyl)-, (1R,2R)- (9CI)
There total 3 articles about Cyclobutanecarboxamide, 1-amino-2-(1-methylethyl)-, (1R,2R)- (9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium dihydroxide;
In
ethanol; acetic acid;
at 20 ℃;
for 4h;
under 760 Torr;
DOI:10.1016/S0957-4166(03)00073-9
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 140 mg / AcOH / dimethylsulfoxide / 96 h / 55 - 60 °C
2: 85 percent / conc. H2SO4 / CH2Cl2 / 0 - 20 °C
3: 95 percent / H2 / 20 percent Pd(OH)2/C / ethanol; acetic acid / 4 h / 20 °C / 760 Torr
With
sulfuric acid; hydrogen; acetic acid;
palladium dihydroxide;
In
ethanol; dichloromethane; acetic acid; dimethyl sulfoxide;
1: asymmetric Strecker reaction;
DOI:10.1016/S0957-4166(03)00073-9
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 85 percent / conc. H2SO4 / CH2Cl2 / 0 - 20 °C
2: 95 percent / H2 / 20 percent Pd(OH)2/C / ethanol; acetic acid / 4 h / 20 °C / 760 Torr
With
sulfuric acid; hydrogen;
palladium dihydroxide;
In
ethanol; dichloromethane; acetic acid;
DOI:10.1016/S0957-4166(03)00073-9