BAX INHIBITING PEPTIDE V5 (BIP-V5)

Base Information

• Chemical Name: BAX INHIBITING PEPTIDE V5 (BIP-V5)
• CAS No.: 579492-81-2
• Molecular Formula: C27H50N6O6S
• Molecular Weight: 586.79
• Mol file: 579492-81-2.mol

Synonyms:BAX INHIBITING PEPTIDE V5 (BIP-V5)

Chemical Property of BAX INHIBITING PEPTIDE V5 (BIP-V5)

Chemical Property:

• Boiling Point: 907.2±65.0 °C(Predicted)
• PKA: 3.31±0.10(Predicted)
• PSA: 232.72000
• Density: 1.185±0.06 g/cm3(Predicted)
• LogP: 4.28730
• Storage Temp.: −20°C
• Solubility.: ≥29.35 mg/mL in DMSO; insoluble in EtOH; ≥91.4 mg/mL in H2O

Purity/Quality:

98%,99%, ^*data from raw suppliers

BaxInhibitorPeptideV5 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Bax inhibitor peptide V5 is an inhibitor of Bax. It decreases levels of the pro-apoptotic proteins Bax, Bad, and NF-?B p65 and increases levels of the anti-apoptotic proteins X-linked inhibitor of apoptosis (XIAP) and Bcl-2 in isolated mouse pancreatic islets when used at a concentration of 100 μM. It inhibits apoptosis induced by etoposide in Hep3B human hepatoma cells when used at a concentration of 200 μM. Bax inhibitor peptide V5 (5 mg/ml, i.c.v.) decreases infarct volume and reduces ipsilateral paw preference in the cylinder rearing test, indicating an improvement in sensorimotor function, in a neonatal mouse model of hypoxic-ischemia brain injury induced by carotid artery ligation. Bax inhibitor peptide V5, when used at a concentration of 100 μM in syngeneic pancreatic islet cells prior to transplantation, inhibits increases in blood glucose levels in an intraperitoneal glucose tolerance test and increases survival in a mouse model of diabetes induced by streptozotocin (STZ; ).