Methanamine, N-[(2-fluorophenyl)methylene]-, N-oxide (9CI)

Base Information

• Chemical Name: Methanamine, N-[(2-fluorophenyl)methylene]-, N-oxide (9CI)
• CAS No.: 578740-19-9
• Molecular Formula: C₈H₈FNO
• Molecular Weight: 153.156
• Mol file: 578740-19-9.mol

Synonyms:Methanamine, N-[(2-fluorophenyl)methylene]-, N-oxide (9CI)

Chemical Property of Methanamine, N-[(2-fluorophenyl)methylene]-, N-oxide (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanamine, N-[(2-fluorophenyl)methylene]-, N-oxide (9CI)

There total 2 articles about Methanamine, N-[(2-fluorophenyl)methylene]-, N-oxide (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

nitromethane (75-52-5) + 2-Fluorobenzaldehyde (446-52-6) → C8H8FN (116529-36-3) + C8H8FNO (54420-31-4,54420-38-1,578740-19-9) + 2-fluorobenzyl alcohol (446-51-5) + 1-fluoro-2-(2-nitro-vinyl)-benzene (399-25-7)

Guidance literature:

With hydrogen; In toluene; at 20 ℃; for 12h; under 10343.2 Torr; Autoclave; High pressure;

DOI:10.1002/anie.201710164

Reference yield:

N-Methylhydroxylamine (593-77-1) + 2-Fluorobenzaldehyde (446-52-6) → N-methyl,α-(2-fluoro)phenyl nitrone (578740-19-9,54420-31-4,54420-38-1)

Guidance literature:

With hydrogenchloride; sodium hydrogencarbonate; In dichloromethane; at 40 ℃; for 2h;

DOI:10.1021/ol0347388

Reference yield: 74.0%

2-methylpropenal (78-85-3,25120-30-3) + C8H8FNO (54420-31-4,54420-38-1,578740-19-9) → (3S,5S)-5-methyl-3-(2-fluorophenyl)-2-methylisoxazolidine-5-carbaldehyde (1245730-33-9)

Guidance literature:

2-methylpropenal; With [Ru(acetone)(R,R-BIPHOP-F)(Cp)][SbF₆]; In dichloromethane; at -5 ℃; for 0.333333h; Inert atmosphere;

C₈H₈FNO; In dichloromethane; at -5 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1055/s-0029-1218788

upstream raw materials:

N-Methylhydroxylamine

2-Fluorobenzaldehyde

nitromethane

Downstream raw materials:

(3S,5S)-5-methyl-3-(2-fluorophenyl)-2-methylisoxazolidine-5-carbaldehyde

Refernces

• 1、 Caddick, Stephen,Bush, Hannah D.. "Synthesis of functionalized sulfonamides via 1,3-dipolar cycloaddition of pentafluorophenyl vinylsulfonate". . p. 2489 - 2492. Retrieved 2007/10/03.