4-Pyrimidinecarboxylicacid,5-ethoxy-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-(9CI)

Base Information

• Chemical Name: 4-Pyrimidinecarboxylicacid,5-ethoxy-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-(9CI)
• CAS No.: 572917-55-6
• Molecular Formula: C₈H₁₀N₂O₅
• Molecular Weight: 214.178
• Mol file: 572917-55-6.mol

Synonyms:4-Pyrimidinecarboxylicacid,5-ethoxy-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-(9CI)

Chemical Property of 4-Pyrimidinecarboxylicacid,5-ethoxy-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-(9CI)

Chemical Property:

• PSA: 101.65000
• LogP: -0.41720

Purity/Quality:

Safty Information:

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Technology Process of 4-Pyrimidinecarboxylicacid,5-ethoxy-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-(9CI)

There total 1 articles about 4-Pyrimidinecarboxylicacid,5-ethoxy-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

ethyl 2-ethoxy(1-methyl-2,5-dioxoimidazolidin-4-ylidene)ethanoate → 5-ethoxy-2-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid (572917-55-6)

Guidance literature:

With potassium hydroxide; for 3h; Heating;

DOI:10.1055/s-2006-926414

Reference yield:

5-ethoxy-2-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid (572917-55-6) → 5-ethoxy-2-(4-methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid ethyl ester

Guidance literature:

Multi-step reaction with 3 steps

1.1: AcCl / 0.33 h / 20 °C

1.2: 98 percent / Heating

2.1: 85 percent / POCl₃; N,N-dimethylaniline / Heating

3.1: 58 percent / [(t-Bu)3PH]BF₄; KF / Pd₂(dba)3 / dioxane / 16 h / 85 °C

With potassium fluoride; N,N-dimethyl-aniline; acetyl chloride; tri tert-butylphosphoniumtetrafluoroborate; trichlorophosphate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In 1,4-dioxane; 3.1: Suzuki coupling;

DOI:10.1055/s-2006-926414

Reference yield:

5-ethoxy-2-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid (572917-55-6) → ethyl 5-ethoxy-2-(2,6-dimethylphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylate

Guidance literature:

Multi-step reaction with 3 steps

1.1: AcCl / 0.33 h / 20 °C

1.2: 98 percent / Heating

2.1: 85 percent / POCl₃; N,N-dimethylaniline / Heating

3.1: 67 percent / K₃PO₄ / Pd(PPh₃)4 / toluene; dimethylformamide / 0.17 h / 200 °C / microwave irradiation

With potassium phosphate; N,N-dimethyl-aniline; acetyl chloride; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene; 3.1: Suzuki coupling;

DOI:10.1055/s-2006-926414

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